SynthesisCancer medicine2024
Assessment and Prediction of Salivary Gland Function After Head and Neck Radiotherapy: A Systematic Review.
Synthesis in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Advanced magnetic resonance imaging techniques for structural and functional assessment of salivary glands.Radiology and oncology · 2026Review
- Ameliorative effects of melatonin on radiotherapy-induced apoptotic and inflammatory responses in rat parotid gland.BMC oral health · 2026Article
- Radiation-induced Xerostomia: Evaluation withMolecular imaging and radionuclide therapy · 2025Article
- Method for Estimating Amount of Saliva Secreted Using a Throat Microphone.Sensors (Basel, Switzerland) · 2025Article
- Parotid preservation or immune protection? The dual dilemma in head and neck cancer radiotherapy.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundModern imaging techniques with magnetic resonance imaging (MRI) or positron emission tomography/computed tomography (PET/CT) have recently been developed to assess radiation-induced damage to salivary structures. The primary aim of this review was to summarize evidence on the imaging modalities used for the assessment and prediction of xerostomia after head and neck radiotherapy (RT).
methodsA systematic review of the literature was performed using successively the MeSH terms "PET," "MRI," "scintigraphy," "xerostomia," and "radiotherapy."
resultsSalivary excretion flow following head and neck RT is correlated with the dose delivered to both parotid and submandibular glands. Salivary gland standardized uptake value extracted from PET/CT following RT has been shown to be correlated with SEF. Models including early SUV decline or ADC increase during RT and clinical parameters can help predict the loss of salivary function after RT.
conclusionsModern imaging parameters appear to be correlated with salivary gland scintigraphy parameters. Models including functional parameters extracted from either PET/CT or MRI unveil new possibilities for adaptive treatment in a selected population of patients.
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