Evidence map›Paper›PMID 39679418›Full record

ArticleRSC advances2024

Synthesis of novel pyridine and pyrazolyl pyridine conjugates with potent cytotoxicity against HepG2 cancer cells as PIM-1 kinase inhibitors and caspase activators.

Mohamed S Nafie, Ahmed Hamza, Ahmed H Moustafa, Hassan A El-Sayed, Samir M El Rayes, Hesham A Morsy, Ahmed Aboelmaged

Abstract read
In one paragraph

Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohamed S NafieDepartment of Chemistry, College of Sciences, University of Sharjah P.O. 27272 Sharjah United Arab Emirates mohamed.elsayed@sharjah.ac.ae.ORCID https://orcid.org/0000-0003-4454-6390
Ahmed HamzaDepartment of Chemistry, Faculty of Science, Suez Canal University Ismailia 41522 Egypt mohamed_nafie@science.suez.edu.eg.
Ahmed H MoustafaDepartment of Chemistry, Faculty of Science, Zagazig University Zagazig 44519 Egypt hasanneg@gmail.com ah_hu_mostafa@yahoo.com.ORCID https://orcid.org/0000-0002-6790-1028
Hassan A El-SayedDepartment of Chemistry, Faculty of Science, Zagazig University Zagazig 44519 Egypt hasanneg@gmail.com ah_hu_mostafa@yahoo.com.ORCID https://orcid.org/0000-0002-4603-0294
Samir M El RayesDepartment of Chemistry, Faculty of Science, Suez Canal University Ismailia 41522 Egypt mohamed_nafie@science.suez.edu.eg.ORCID https://orcid.org/0000-0003-2667-3855
Hesham A MorsyHigher Institution of Engineering & Modern Technology El Marg Cairo Egypt.
Ahmed AboelmagedDepartment of Chemistry, Faculty of Science, Suez Canal University Ismailia 41522 Egypt mohamed_nafie@science.suez.edu.eg.ORCID https://orcid.org/0000-0002-1465-9274

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel series of nicotinonitrile and pyrazolyl nicotinonitrile were synthesized, and their PIM-1 kinase inhibitors and caspase activators were investigated. New Manich bases 6-8 were synthesized

Identifiers

PMID39679418
PMCPMC11638703

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.