Evidence map›Paper›PMID 39679382›Full record

ArticleProceedings of the ... ACM International Conference on Information & Knowledge Management. ACM International Conference on Information and Knowledge Management2024

iMIRACLE: an Iterative Multi-View Graph Neural Network to Model Intercellular Gene Regulation from Spatial Transcriptomic Data.

Ziheng Duan, Siwei Xu, Cheyu Lee, Dylan Riffle, Jing Zhang

Abstract read
In one paragraph

Article in Proceedings of the ... ACM International Conference on Information & Knowledge Management. ACM International Conference on Information and Knowledge Management, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. MUSE: A Multi-slice Joint Analysis Method for Spatial Transcriptomics Experiments.Proceedings of the ... ACM International Conference on Information & Knowledge Management. ACM International Conference on Information and Knowledge Management · 2025
    Article
  4. DISCO: A DIFFUSION MODEL FOR SPATIAL TRANSCRIPTOMICS DATA COMPLETION.Proceedings. International Conference on Image Processing · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ziheng DuanUniversity of California, Irvine, Irvine, CA, USA.
Siwei XuUniversity of California, Irvine, Irvine, CA, USA.
Cheyu LeeUniversity of California, Irvine, Irvine, CA, USA.
Dylan RiffleUniversity of California, Irvine, Irvine, CA, USA.
Jing ZhangUniversity of California, Irvine, Irvine, CA, USA.

Funding

Interpretable Deep Learning Methods to Investigate Genetics and Epigenetics of Alzheimer's Disease at a Single-Cell ResolutionR01NS128523 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI JING ZHANG · 2022 to 2026
$3.2M
Decoding the Noncoding Regulatory Genome with Super-resolution via Single-cell Multiomics IntegrationR01HG012572 · NHGRI · UNIVERSITY OF CALIFORNIA-IRVINE · PI JING ZHANG · 2022 to 2026
$2.0M
NHGRI NIH HHS R01 HG012572NINDS NIH HHS R01 NS128523
6 · The paper itself

Abstract

Spatial transcriptomics has transformed genomic research by measuring spatially resolved gene expressions, allowing us to investigate how cells adapt to their microenvironment via modulating their expressed genes. This essential process usually starts from cell-cell communication (CCC) via ligand-receptor (LR) interaction, leading to regulatory changes within the receiver cell. However, few methods were developed to connect them to provide biological insights into intercellular regulation. To fill this gap, we propose iMiracle, an iterative multi-view graph neural network that models each cell's intercellular regulation with three key features. Firstly, iMiracle integrates inter- and intra-cellular networks to jointly estimate

Indexed as

cell–ell communicationsgraph neural networksinter-cellular gene regulationspatial transcriptomics

Identifiers

PMID39679382
PMCPMC11639074

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.