Evidence map›Paper›PMID 39679206›Full record

ArticleIJTLD open2024

Detection of other pathologies when utilising computer-assisted digital solutions for TB screening.

J Sebastian, I D Olaru, A Giannakis, M Arentz, S V Kik, M Ruhwald, S Linsen, G Günther, P Wolf, F J Herth and 2 more

Abstract read
In one paragraph

Article in IJTLD open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. The role of medical imaging in translational research into early pulmonary tuberculosis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

J SebastianDivision of Infectious Disease and Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany.
I D OlaruDivision of Infectious Disease and Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany.
A GiannakisDiagnostic and Interventional Radiology, Heidelberg University Hospital, Heidelberg, Germany.
M ArentzFIND, Geneva, Switzerland.
S V KikFIND, Geneva, Switzerland.
M RuhwaldFIND, Geneva, Switzerland.
S LinsenFIND, Geneva, Switzerland.
G GüntherDepartment of Pulmonology and Allergology, Inselspital, Bern University Hospital, Bern, Switzerland.
P WolfDepartment for Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Heidelberg, Germany.
F J HerthDepartment for Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Heidelberg, Germany.
T WeberDiagnostic and Interventional Radiology, Heidelberg University Hospital, Heidelberg, Germany.
C M DenkingerDivision of Infectious Disease and Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComputer-aided detection (CAD) tools for TB detection have the potential to enable screening programmes and reduce the diagnostic gap in settings where access to radiologists is limited. However, there are concerns that other common chest X-ray (CXR) abnormalities not due to TB may be missed.

methodsWe assessed the performance of three commercialised CAD tools (qXR, INSIGHT CXR and DrAID

resultsThe 517 CXRs included were deemed abnormal by the three CAD with a sensitivity of respectively 97% (95% CI 95-98), 94% (95% CI 91-95), and 87% (95% CI 84-90) for INSIGHT CXR, qXR, and DrAID. The CAD generally detected abnormalities in patients with critical diagnoses such as lung cancer or heart failure. Performance for detecting other abnormalities was variable.

conclusionThis study showed that the three CAD tools identified CXRs as abnormal when diseases other than TB were present. Our findings alleviate ethical concerns of missing abnormalities other than TB when using commercially available CAD for TB screening and show their potential broader applicability.

Indexed as

artificial intelligenceCADchest X-raynon-communicable diseasestuberculosis screening

Identifiers

PMID39679206
PMCPMC11636493

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.