ArticleJournal of thoracic disease2024
Efficacy and safety of applying oxidized regenerated cellulose sheets to the parietal pleura of open chest wounds in thoracic surgery: a prospective randomized controlled trial protocol.
Article in Journal of thoracic disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Clarifications on a prospective randomized controlled trial evaluating adhesion prevention using oxidized regenerated cellulose sheets in thoracic surgery.Journal of thoracic disease · 2025Article
- Oxidized regenerated cellulose in thoracic surgery: potential game-changer or hidden danger?Journal of thoracic disease · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: According to a large-scale clinical trial in Japan, segmentectomy for small peripheral non-small cell lung cancer has an advantage over lobectomy in terms of overall survival, while it could also increase the incidence of local recurrence. In ipsilateral reoperations, intrathoracic adhesions from a previous surgery increase the risk of lung injury and bleeding, which may result in intraoperative and postoperative complications. The ability of oxidized regenerated cellulose (ORC) sheets to prevent postoperative adhesions has been demonstrated in the abdomen, and the same effect is expected in the thoracic region. The purpose of this study is to provide evidence supporting the application of ORC sheets to the parietal pleura of an open chest wounds to prevent postoperative adhesions in the thoracic region. Methods: This phase II prospective open-label, randomized, parallel-group study will validate adhesion prevention by applying ORC sheets to the parietal pleura of open chest wounds at the time of surgical closure. In the control group, the chest is closed by the usual procedure without ORC sheets. The primary endpoint is the presence rate of pleural adhesion findings on chest echography performed 4-20 weeks postoperatively. Data analysis will be performed in 2025-2026. Discussion: This study will provide evidence to the adhesion prevention effect of ORC sheet in the thoracic region, with the aim of establishing a strategy to prevent postoperative intrapleural adhesions. Trial Registration: This trial has been registered on the Japan Registry of Clinical Trials 1032230271 (https://jrct.niph.go.jp/latest-detail/jRCT1032230271).
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