ArticleJournal of thoracic disease2024
Prognostic value of ubiquitination-related differentially expressed genes in esophageal squamous cell carcinoma: a comprehensive analysis and future directions.
Article in Journal of thoracic disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- Comprehensive big data analysis reveals SLC10A3 as a potential biomarker in head and neck cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Comprehensive analysis based on the ubiquitination- and deubiquitylation-related genes reveals the function of NEURL3 in esophageal squamous cell carcinoma.Frontiers in immunology · 2025Article
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Authors and funding
11 authors.
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Abstract
Background: Esophageal squamous cell carcinoma (ESCC) represents a considerable health challenge, primarily due to its poor prognosis and the limited availability of effective therapeutic interventions. Ubiquitination, a vital post-translational modification, is integral to cellular regulation; nonetheless, its role in ESCC has not been thoroughly explored. This study aims to identify ubiquitination-related differentially expressed genes (URDEGs) that possess prognostic significance in the context of ESCC. Methods: We conducted a comprehensive analysis using The Cancer Genome Atlas ESCC (TCGA-ESCC) dataset, GSE20347, and an in-house ESCC dataset to identify URDEGs. The limma R package was used to determine the intersection of ubiquitination-related genes (URGs) with common differentially expressed genes (Co-DEGs) for differential expression analysis. To evaluate prognostic value, Kaplan-Meier survival analysis was conducted, while functional enrichment was examined using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Validation was performed using real-time quantitative polymerase chain reaction. Results: Eighty-five URDEGs were identified, with five key genes ( Conclusions: The results of our study highlight the prognostic significance of URDEGs in ESCC, suggesting that they may serve as useful biomarkers and therapeutic targets. Future research should focus on clinical validation and the development of targeted therapies to improve the outcomes of patients with ESCC.
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