Evidence map›Paper›PMID 39678795›Full record

ArticleWorld journal of gastrointestinal oncology2024

Mixed pancreatic ductal adenocarcinoma and well-differentiated neuroendocrine tumor: A case report.

Xiaofeng Zhao, Tina Bocker Edmonston, Ronald Miick, Upasana Joneja

Abstract readCase Reports
In one paragraph

Article in World journal of gastrointestinal oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiaofeng ZhaoDepartment of Pathology, Cooper University Hospital, Camden, NJ 08103, United States. zhao-xiaofeng@cooperhealth.edu.
Tina Bocker EdmonstonDepartment of Pathology, Cooper University Hospital, Camden, NJ 08103, United States.
Ronald MiickDepartment of Pathology, Cooper University Hospital, Camden, NJ 08103, United States.
Upasana JonejaDepartment of Pathology, Cooper University Hospital, Camden, NJ 08103, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPancreatic mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are rare malignancies affecting the pancreas. The World Health Organization defines MiNENs as neoplasms composed of morphologically recognizable neuroendocrine and non-neuroendocrine components, each constituting 30% or more of the tumor volume. Adenocarcinoma-neuroendocrine carcinoma is the most frequent MiNEN combination. A well-differentiated neuroendocrine tumor (NET) component is rarely reported in MiNENs. CASE SUMMARY: Here we report a rare case with intermingled components of ductal adenocarcinoma and grade 1 well-differentiated NET in the pancreas. The two tumors show distinct histology and significant differentiation discrepancy (poorly differentiated high grade adenocarcinoma and well-differentiated low grade NET), and also present as metastases in separate lymph nodes. Next generation sequencing of the two components demonstrates

conclusionMixed NET/non-NET tumors with distinct histology and molecular profiles might be better classified as collision tumors rather than MiNENs.

Indexed as

Case reportCollision tumorGrade 1 well-differentiated neuroendocrine tumorMolecular profilePancreatic adenocarcinomaPancreatic mixed neuroendocrine-non-neuroendocrine neoplasms

Identifiers

PMID39678795
PMCPMC11577375

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.