Evidence map›Paper›PMID 39678628›Full record

ArticleRedox biochemistry and chemistry2024

Boronate-Based Bioactive Compounds Activated by Peroxynitrite and Hydrogen Peroxide.

Monika Rola, Jacek Zielonka, Renata Smulik-Izydorczyk, Jakub Pięta, Karolina Pierzchała, Adam Sikora, Radosław Michalski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biochemistry and chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Monika RolaInstitute of Applied Radiation Chemistry, Department of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
Jacek ZielonkaDepartment of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States.
Renata Smulik-IzydorczykInstitute of Applied Radiation Chemistry, Department of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
Jakub PiętaInstitute of Applied Radiation Chemistry, Department of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
Karolina PierzchałaInstitute of Applied Radiation Chemistry, Department of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
Adam SikoraInstitute of Applied Radiation Chemistry, Department of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.
Radosław MichalskiInstitute of Applied Radiation Chemistry, Department of Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland.

Funding

Targeting phenethyl isothiocyanate to mitochondria in lung carcinogenesisR01CA280746 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI MING YOU, Jacek M Zielonka · 2024 to 2026
$1.9M
NCI NIH HHS R01 CA280746
6 · The paper itself

Abstract

Boronates react directly and stoichiometrically with peroxynitrite and hydrogen peroxide. For this reason, boronates have been widely used as peroxynitrite- and hydrogen peroxide-sensitive moieties in various donors of bioactive compounds. So far, numerous boronate-based prodrugs and theranostics have been developed, characterized, and used in biological research. Here, the kinetic aspects of their activation are discussed, and the potential benefits of modifying their original structure with a boronic or boronobenzyl moiety are described.

Indexed as

boronic acidsboronic estershydrogen peroxideperoxynitriteprodrugtheranostics

Identifiers

PMID39678628
PMCPMC11637410

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.