ReviewAmerican journal of translational research2024
Microbial harmony in female reproductive health: exploring the impact of intestinal flora on ovarian function and disease pathogenesis.
Review in American journal of translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Gut Microbiota Metabolic Reprogramming Drives Endocrine and Immune Resistance in Hormone-Dependent Cancers.Cancers · 2026Review
- Immunometabolic-uterine-ovarian interactions and flushing therapy in dairy cows: a narrative review.Veterinary world · 2026Review
- Pathogenic mechanisms and therapeutic potential of the microbiome in premature ovarian insufficiency.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intestinal microbiota is vast in type and quantity and it plays a critical role in regulating various physiological functions in the host, including intestinal function, immune response and energy metabolism. Existing research shows that intestinal flora is associated with various hormones, cell cycles and ovarian function-related diseases in the female ovaries. Certain microorganisms within the intestinal flora can modulate the levels of hormones secreted by the ovary, such as estrogen and androgens. Furthermore, an imbalance in the gut microbiota can result in altered hormone levels in the host, potentially leading to related diseases. Studies have found that a variety of ovarian function-related diseases are closely related to intestinal flora, such as polycystic ovary syndrome (PCOS), ovarian insufficiency (POI), endometriosis (EMS) and ovarian cancer. Importantly, ovarian function-related diseases are notably difficult to diagnose early and often require prolonged treatment for effective management. The microbiota and its metabolites in patients with ovarian function-related diseases and cancers can serve as valuable biomarkers for early diagnosis, offering novel strategies for disease screening, treatment stratification, and prognosis.
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Registered trials
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