ArticleAmerican journal of translational research2024
Efficacy and safety of safflower yellow combined with low molecular weight heparin in preventing deep vein thrombosis after orthopedic surgery: a systematic review and meta-analysis.
Article in American journal of translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- The novel anticoagulant dabigatran versus enoxaparin for thromboprophylaxis following total hip replacement: a meta-analysis.BMC cardiovascular disorders · 2026Pooled it
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis systematic review and meta-analysis aims to evaluate the efficacy and safety of safflower yellow (SY) combined with low molecular weight heparin (LMWH) in preventing deep vein thrombosis (DVT) after orthopedic surgery.
methodsWe conducted a comprehensive investigation of PubMed, EMbase, Cochrane Library, CNKI, VIP, and Wanfang databases to identify randomized controlled trials (RCTs) from January 2000 to March 2024. These trials compared the efficacy of SY combined with LMWH versus LMWH alone in preventing post-surgical DVT. Primary outcomes were the incidence of DVT, activated partial thromboplastin time (APTT), and prothrombin time (PT). The methodological quality of included studies was assessed using the modified Jadad scale. The meta-analysis, conducted with using RevMan 5.3 and STATA, employed fixed or random-effects models depending on heterogeneity assessments. It calculated risk ratios (RR) for DVT incidence and mean differences for APTT/PT, while also evaluating robustness and publication bias. Significance thresholds were set at P < 0.05 and P < 0.1, respectively.
resultsOur analysis included eight RCTs involving 624 patients. The meta-analysis revealed that the combination of SY and LMWH significantly reduced the incidence of DVT (RR: 0.29, 95% CI: 0.16-0.52) compared to LMWH alone, with no difference in adverse reaction rate. Additionally, the combination therapy demonstrated improved APTT and PT profiles.
conclusionThe combination of SY and LMWH is more effective than LMWH alone for preventing DVT post orthopedic surgery, offering a promising alternative for thromboprophylaxis in these patients.
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Registered trials
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