Evidence map›Paper›PMID 39678343›Full record

ArticleResearch square2024

Fatty Acid Synthase-Derived Lipid Stores Support Breast Cancer Metastasis.

Chaylen Andolino, Eylem Kulkoyluoglu Cotul, Zilin Xianyu, Yun Li, Divya Bhat, Mitchell Ayers, Kimberly K Buhman, Stephen D Hursting, Michael K Wendt, Dorothy Teegarden

Abstract readPreprint
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Chaylen AndolinoPurdue University West Lafayette.
Eylem Kulkoyluoglu CotulPurdue University West Lafayette.
Zilin XianyuPurdue University West Lafayette.
Yun LiUniversity of Iowa.
Divya BhatUniversity of Iowa.
Mitchell AyersPurdue University West Lafayette.
Kimberly K BuhmanPurdue University West Lafayette.
Stephen D HurstingUniversity of North Carolina at Chapel Hill.
Michael K WendtUniversity of Iowa.
Dorothy TeegardenPurdue University West Lafayette.

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4M
Indiana Clinical and Translational Science Institute (UL1)UL1TR000006 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI SHEKHAR, ANANTHA · 2012 to 2013
$5.6M
Obesity, Metabolism and Breast Cancer MetastasisR01CA232589 · NCI · PURDUE UNIVERSITY · PI HURSTING, STEPHEN D, TEEGARDEN, DOROTHY · 2019 to 2023
$2.6M
Impact of hypoxia on lipid metabolism in obesity-driven breast cancer progressionR01CA271597 · NCI · PURDUE UNIVERSITY · PI Stephen D Hursting, Dorothy Teegarden · 2023 to 2026
$2.5M
NCATS NIH HHS UL1 TR000006NCI NIH HHS P30 CA023168NCI NIH HHS R01 CA232589NCI NIH HHS R01 CA271597
6 · The paper itself

Abstract

Lipid accumulation is associated with breast cancer metastasis. However, the mechanisms underlying how breast cancer cells increase lipid stores and their functional role in disease progression remain incompletely understood. Herein we quantified changes in lipid metabolism and characterized cytoplasmic lipid droplets in metastatic versus non-metastatic breast cancer cells.

Indexed as

breast cancerFASNfatty acidsfatty acid synthaselipid dropletlipid metabolismlipid storagemass spectrometrymetastasisTNBC

Identifiers

PMID39678343
PMCPMC11643320

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.