ArticleVascular health and risk management2024
Relationship Between the Hemoglobin-to-Red Cell Distribution Width Ratio and in-Hospital Mortality in Patients with Chronic Heart Failure.
Article in Vascular health and risk management, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Combined diagnostic value of rheumatoid arthritis-specific citrullinated protein, haemoglobin-to-red cell distribution width ratio, and anti-CCP antibody in rheumatoid arthritis.Annals of medicine · 2026Article
- The incremental prognostic effect of red blood cell distribution width in 28-day mortality among critically ill patients with HFpEF.American heart journal plus : cardiology research and practice · 2026Article
- Association between hemoglobin-to-red blood cell distribution width ratio trajectory patterns and in-hospital mortality in critically ill patients with cirrhosis: a retrospective cohort study based on MIMIC-IV and eICU-CRD.BMC medical informatics and decision making · 2026Article
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- Correlation analysis of serum PACAP-38, fibulin-3 and TEM1 levels with cardiac function and prognosis in chronic heart failure patients.Journal of medical biochemistry · 2026Article
- Hemoglobin-to-Red Cell Distribution Width Ratio as a Prognostic Marker in Decompensated Heart Failure Patients: A Prospective Observational Study.Life (Basel, Switzerland) · 2026Article
- Predictive value of hemoglobin-to-red cell distribution width ratio for mortality in new-onset atrial fibrillation after cardiac surgery a machine learning study based on the MIMIC-IV database.BMC cardiovascular disorders · 2026Article
- Hemoglobin-to-Red Cell Distribution Width Ratio and Vitamin D Status as Early Predictors of Cardiovascular Risk in Primary Sjögren's Syndrome.Life (Basel, Switzerland) · 2026Article
- The hemoglobin-red blood cell distribution width ratio is a reliable predictor of recurrence of ketoacidosis in patients with type 2 diabetes.Frontiers in endocrinology · 2026Article
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- Machine learning model and hemoglobin to red cell distribution width ratio evaluates all-cause mortality in pulmonary embolism.Scientific reports · 2025Article
- Hemoglobin-to-Red Cell Distribution Width Ratio Was Associated with Cardiovascular Diseases and Death.Journal of clinical medicine · 2025Article
- Development of a Nomogram for Predicting Multiple Organ Dysfunction in Acute Pancreatitis.Journal of inflammation research · 2025Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Purpose: Hemoglobin (Hb) levels and red cell distribution width (RDW) are standard and widely used parameters that predict clinical outcomes in patients with chronic heart failure (CHF). The Hb to RDW ratio (HRR) provides an incremental clinical prediction, as it reflects the various clinical characteristics of patients. No published data exists in the Medical Information Mart for Intensive Care (MIMIC-IV) and eICU Collaborative Research Database (eICU-CRD) databases on HRR and its association with in-hospital mortality among patients with CHF. The aim of this study was to evaluate the relationship between the HRR and in-hospital mortality in two large real-world cohorts of patients with chronic CHF. Patients and Methods: Data from the MIMIC-IV and eICU-CRD databases were used to explore the association between HRR and in-hospital mortality. Multivariate logistic regression, stratified analysis with interaction, and restricted cubic splines were used to investigate the association between HRR and in-hospital mortality. Results: A total of 30,411 patients with CHF were enrolled based on the MIMIC-IV and multicenter eICU-CRD databases (15,983 and 14,428, respectively), including 16,295 men and 14,116 women with a median age of 73 years. The mean HRR was 0.69 ± 0.20. The overall in-hospital mortality rate was 12.63%. Increasing quantiles of HRR were associated with reduced in-hospital mortality rates. After adjusting for significant predictors, multivariate logistic regression analysis demonstrated that a low HRR was a significant predictor of in-hospital mortality, with a graded reduction in risk as HRR increased. Sensitivity analysis using restricted cubic splines demonstrated a continuous increase in in-hospital mortality risk with decreasing HRR (P = 0.262 for the non-linear model). Conclusion: A linear relationship was observed between baseline HRR levels and in-hospital mortality. Lower HRR levels were associated with higher in-hospital mortality in patients with CHF. HRR could be a reliable clinical metric for assessing in-hospital mortality risk.
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