ArticleCureus2024
Enhancing Nerve Function and Reviving the Unrecordable: A Comprehensive Analysis of the Effects of a Dual Hydrodissection Protocol on Clinical and Nerve Conduction Parameters in Mild-Moderate and Severe Carpal Tunnel Syndrome.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study evaluates the efficacy of a sequential dual one-month interval hydrodissection (HD) protocol in mild-moderate as well as severe carpal tunnel syndrome (CTS) cases, with a comprehensive analysis of clinical and electrophysiological outcomes.
methodsA retrospective analysis was conducted on 286 patients (379 wrists) treated between 2021 and 2024 at two centers in India. The enrolled patient population was divided into mild-moderate and severe CTS subgroups. The dual HD protocol comprised an initial HD with methylprednisolone acetate followed by another with 5% dextrose in water (D5W) one month later. Clinical and electrophysiological characteristics were assessed and compared at baseline and three months after initiating the treatment. Outcomes were measured in terms of Visual Analog Scale (VAS) scores, Boston Carpal Tunnel Questionnaire (BCTQ) scores, and nerve conduction studies (NCS) parameters.
resultsThe number of patients categorized into mild-moderate and severe subgroups was 239 (321 wrists) and 47 (58 wrists), respectively. Significant improvements were noted among both subgroups. In the mild-moderate subgroup, mean VAS scores decreased from 2.03 to 0.12 (p<0.001). BCTQ functional and severity scores also showed a significant improvement (p<0.001). In the severe subgroup, mean VAS scores decreased from 7.43 to 2.12 (p<0.001), and BCTQ scores also decreased significantly (p<0.001). The key highlight of the study was significant electrophysiological improvement, with 71% of the severe CTS patients showing recordable sensory nerve action potentials (SNAPs) that were non-recordable at baseline.
conclusionThe dual HD protocol was efficacious in improving clinical as well as electrophysiological outcomes in both mild-moderate and severe CTS patients. This study presents the dual HD strategy as a potentially effective minimally invasive alternative to surgery in severe cases where surgical intervention is the conventional treatment. Further randomized controlled trials with a longer follow-up period are warranted to validate these findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.