Evidence map›Paper›PMID 39677806›Full record

ArticlebioRxiv : the preprint server for biology2024

Unusually Rapid Isomerization of Aspartic Acid in Tau.

Thomas A Shoff, Brielle Van Orman, Vivian C Onwudiwe, Joseph C Genereux, Ryan R Julian

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Thomas A ShoffDepartment of Chemistry, University of California, Riverside, California 92521, United States.
Brielle Van OrmanDepartment of Chemistry, University of California, Riverside, California 92521, United States.
Vivian C OnwudiweDepartment of Chemistry, University of California, Riverside, California 92521, United States.
Joseph C GenereuxDepartment of Chemistry, University of California, Riverside, California 92521, United States.ORCID 0000-0002-5093-7710
Ryan R JulianDepartment of Chemistry, University of California, Riverside, California 92521, United States.ORCID 0000-0003-1580-8355

Funding

Connecting long-lived protein isomerization to lysosomal failure in Alzheimer's diseaseR01AG066626 · NIA · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI JULIAN, RYAN ROY · 2020 to 2024
$2.8M
NIA NIH HHS R01 AG066626
6 · The paper itself

Abstract

Spontaneous chemical modifications in long-lived proteins can potentially change protein structure in ways that impact proteostasis and cellular health. For example, isomerization of aspartic acid interferes with protein turnover and is anticorrelated with cognitive acuity in Alzheimer's disease. However, few isomerization rates have been determined for Asp residues in intact proteins. To remedy this deficiency, we used protein extracts from SH-SY5Y neuroblastoma cells as a source of a complex, brain-relevant proteome with no baseline isomerization. Cell lysates were aged

Indexed as

agingAlzheimer’s diseaseaspartic aciddata-independent acquisitionisomerizationliquid chromatography-mass spectrometry

Identifiers

PMID39677806
PMCPMC11643016

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.