Evidence map›Paper›PMID 39677794›Full record

ArticlebioRxiv : the preprint server for biology2024

Peripheral immune cell response to stimulation stratifies Parkinson's disease progression from prodromal to clinical stages.

Julian R Mark, Ann M Titus, Hannah A Staley, Stephan Alvarez, Savanna Mahn, Nikolaus R McFarland, Rebecca L Wallings, Malú Gámez Tansey

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Julian R MarkDepartment of Neuroscience, University of Florida, College of Medicine, Gainesville, FL 32610, USA.ORCID 0000-0003-4152-7725
Ann M TitusDepartment of Neuroscience, University of Florida, College of Medicine, Gainesville, FL 32610, USA.ORCID 0000-0002-1293-1350
Hannah A StaleyDepartment of Neuroscience, University of Florida, College of Medicine, Gainesville, FL 32610, USA.ORCID 0009-0001-8284-6178
Stephan AlvarezDepartment of Neurology and Norman Fixel Institute for Neurological Diseases, University of Florida Health, Gainesville, FL 32608, USA.
Savanna MahnDepartment of Neurology and Norman Fixel Institute for Neurological Diseases, University of Florida Health, Gainesville, FL 32608, USA.
Nikolaus R McFarlandDepartment of Neurology and Norman Fixel Institute for Neurological Diseases, University of Florida Health, Gainesville, FL 32608, USA.ORCID 0000-0002-8699-8857
Rebecca L WallingsDepartment of Neuroscience, University of Florida, College of Medicine, Gainesville, FL 32610, USA.ORCID 0000-0003-3878-291X
Malú Gámez TanseyDepartment of Neuroscience, University of Florida, College of Medicine, Gainesville, FL 32610, USA.ORCID 0000-0002-1719-4708

Funding

Networking and Expanding Undergraduate Research on the Neurobiology of Aging to Advance DiversityR25AG076396 · NIA · UNIVERSITY OF FLORIDA · PI ABISAMBRA, JOSE FRANCISCO, ALVINA, KARINA · 2022 to 2024
$1.1M
NIA NIH HHS R25 AG076396
6 · The paper itself

Abstract

The motor stage of idiopathic Parkinson's disease (iPD) can be preceded for years by a prodromal stage characterized by non-motor symptoms like REM sleep behavior disorder (RBD). Here, we show that multiple stages of iPD, including the pre-motor prodromal stage, can be stratified according to the inflammatory and immunometabolic responses to stimulation of peripheral blood mononuclear cells

Identifiers

PMID39677794
PMCPMC11643067

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.