Evidence map›Paper›PMID 39677792›Full record

ArticlebioRxiv : the preprint server for biology2024

Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients.

Haley E Randolph, Raúl Aguirre-Gamboa, Elsa Brunet-Ratnasingham, Tomoko Nakanishi, Veronica Locher, Ellen Ketter, Cary Brandolino, Catherine Larochelle, Alexandre Prat, Nathalie Arbour and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Haley E RandolphDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0003-2044-1180
Raúl Aguirre-GamboaSection of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA.ORCID 0000-0003-2505-3574
Elsa Brunet-RatnasinghamDepartment of Medicine, University of California San Francisco, CA, USA.ORCID 0000-0002-3613-1315
Tomoko NakanishiLady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada.ORCID 0000-0001-9510-5646
Veronica LocherCommittee on Immunology, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-2068-1195
Ellen KetterCommittee on Microbiology, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-2153-2167
Cary BrandolinoSection of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA.
Catherine LarochelleDepartment of Neurosciences, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.
Alexandre PratDepartment of Neurosciences, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.ORCID 0000-0001-6188-0580
Nathalie ArbourDepartment of Neurosciences, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.ORCID 0000-0002-3718-1584
Anne DumaineSection of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL, USA.
Andrés FinziCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada.ORCID 0000-0002-4992-5288
Madeleine DurandCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada.
J Brent RichardsLady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada.ORCID 0000-0002-3746-9086
Daniel E KaufmannCentre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC, Canada.ORCID 0000-0003-4467-136X
Luis B BarreiroCommittee on Genetics, Genomics, and Systems Biology, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-9456-367X

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI LIU, CAMBRIAN YANGSHAO · 1990 to 2025
$29.8M
Characterizing the impact of Yersinia Pestis to the phenotypic evolution of the human immune systemR01GM134376 · NIGMS · UNIVERSITY OF CHICAGO · PI BARREIRO, LUIS BRUNO · 2019 to 2022
$2.2M
Characterizing the genetic and evolutionary determinants of population variation in transcriptional responses to pathogensR35GM152227 · NIGMS · UNIVERSITY OF CHICAGO · PI Luis Bruno Barreiro · 2024 to 2026
$1.6M
Genetic determinants of inter-individual variation in the dynamic transcriptional innate immune response to Mycobacterium tuberculosisF31HL156419 · NHLBI · UNIVERSITY OF CHICAGO · PI RANDOLPH, HALEY ELIZABETH · 2021 to 2022
$93k
NHLBI NIH HHS F31 HL156419NIDDK NIH HHS P30 DK042086NIGMS NIH HHS R01 GM134376NIGMS NIH HHS R35 GM152227
6 · The paper itself

Abstract

Genome-wide association studies performed in patients with coronavirus disease 2019 (COVID-19) have uncovered various loci significantly associated with susceptibility to SARS-CoV-2 infection and COVID-19 disease severity. However, the underlying

Indexed as

COVID-19expression quantitative trait loci (eQTL)gene-environment interactionsSARS-CoV-2 infectionsingle-cell RNA-seq

Identifiers

PMID39677792
PMCPMC11642875

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.