ArticlebioRxiv : the preprint server for biology2024
PD-L1 expression is mediated by microRNA processing, Wnt/β-catenin signaling, and chemotherapy in Wilms tumor.
Kavita Desai, Patricia D B Tiburcio, Austin Warne, Arash Nabbi, Serena Zhou, Sean D Reiff, Matthew E Campbell, Kenneth S Chen
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
8 authors.
Kavita DesaiDivision of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.
Patricia D B TiburcioDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
Austin WarneDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
Arash NabbiPrincess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Serena ZhouDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
Sean D ReiffDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
Matthew E CampbellDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
Kenneth S ChenDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.ORCID 0000-0003-2304-4631 Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8MUT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2010 to 2026
$53.7MUniversity of Texas Southwestern Medical Center SPORE in Kidney CancerP50CA196516 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Payal Kapur, Payal Kapur · 2016 to 2026
$24.7MDevelopmental transcription factors in Drosha-driven cancerR01CA289259 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kenneth Sung-Man Chen · 2024 to 2026
$2.2MThe role of PLAG1 in Wilms tumor formationK08CA207849 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI CHEN, KENNETH SUNG-MAN · 2017 to 2021
$781kFunctional Proteomics by Reverse Phase Protein Array in CancerR50CA221675 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LU, YILING · 2017 to 2021
$726kLaser Scanning Confocal for UT Southwestern Live Cell Imaging FacilityS10OD021684 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI LUBY-PHELPS, KATHERINE J · 2016 to 2016
$455kNCI NIH HHS K08 CA207849NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA142543NCI NIH HHS P50 CA196516NCI NIH HHS R01 CA289259NCI NIH HHS R50 CA221675NIH HHS S10 OD021684
6 · The paper itselfAbstract
Inhibition of immune checkpoint proteins is effective in adult cancers but has shown limited efficacy in pediatric cancers. While factors regulating expression of immune checkpoint proteins such as PD-L1 are well-documented in adult cancers, their regulation is poorly understood in pediatric cancers. Here, we show that PD-L1 is upregulated in distinct subsets of Wilms tumor, the most common pediatric kidney cancer. Specifically, chemotherapy-exposed Wilms tumor specimens exhibited higher levels of PD-L1 expression, and common chemotherapeutics upregulated PD-L1 in childhood cancer cell lines
Identifiers
PMID39677784
PMCPMC11642745
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