Evidence map›Paper›PMID 39677777›Full record

ArticlebioRxiv : the preprint server for biology2025

BindCraft: one-shot design of functional protein binders.

Martin Pacesa, Lennart Nickel, Christian Schellhaas, Joseph Schmidt, Ekaterina Pyatova, Lucas Kissling, Patrick Barendse, Jagrity Choudhury, Srajan Kapoor, Ana Alcaraz-Serna and 19 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors.

Christian SchellhaasORCID 0000-0001-7367-1620
Ekaterina Pyatova
Patrick Barendse
Jagrity Choudhury
Srajan Kapoor
Ana Alcaraz-Serna
Kourosh H Ghamary
Laura Vinué
Brahm J Yachnin
Andrew M Wollacott
Stephen Buckley
Adrie H Westphal
Simon Lindhoud
Sandrine GeorgeonORCID 0000-0002-8158-4508
Georgios N HatzopoulosORCID 0000-0003-4382-4459
Pierre Gönczy
Daan C Swarts
Alex J Vecchio
Bernard L Schneider
Sergey OvchinnikovORCID 0000-0003-2774-2744

Funding

Structure and Assembly of Membrane Proteins at Tight JunctionsR35GM138368 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI Alex J. Vecchio · 2020 to 2026
$3.1M
NIGMS NIH HHS R35 GM138368
6 · The paper itself

Abstract

Protein-protein interactions (PPIs) are at the core of all key biological processes. However, the complexity of the structural features that determine PPIs makes their design challenging. We present BindCraft, an open-source and automated pipeline for

Identifiers

PMID39677777
PMCPMC11642741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.