Evidence map›Paper›PMID 39677765›Full record

ArticlebioRxiv : the preprint server for biology2025

Mesoscale simulations of membrane-tethered reactions to parameterize cell-scale models of signaling.

Kelvin J Peterson, Boris M Slepchenko, Leslie M Loew

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Kelvin J PetersonR. D. Berlin Center for Cell Analysis and Modeling, University of Connecticut School of Medicine, Farmington, CT USA.
Boris M SlepchenkoR. D. Berlin Center for Cell Analysis and Modeling, University of Connecticut School of Medicine, Farmington, CT USA.
Leslie M LoewR. D. Berlin Center for Cell Analysis and Modeling, University of Connecticut School of Medicine, Farmington, CT USA.ORCID 0000-0002-1851-4646

Funding

Mechanistic Modeling of Cellular SystemsR24GM137787 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Pedro Mendes, Ion I. Moraru · 2020 to 2026
$8.9M
Mesoscale spatial kinetic modeling of cell systemsR01GM132859 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LOEW, LESLIE M · 2019 to 2022
$1.4M
NIGMS NIH HHS R01 GM132859NIGMS NIH HHS R24 GM137787
6 · The paper itself

Abstract

Biochemical interactions at membranes are the starting points for cell signaling networks. But bimolecular reaction kinetics are difficult to experimentally measure on 2-dimensional membranes and are usually measured in volumetric

Identifiers

PMID39677765
PMCPMC11643039

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.