Evidence map›Paper›PMID 39677757›Full record

ArticlebioRxiv : the preprint server for biology2024

Mechanism of small heat shock protein client sequestration and induced polydispersity.

Adam P Miller, Steve L Reichow

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Adam P MillerDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland OR 97239, U.S.A.
Steve L ReichowDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland OR 97239, U.S.A.ORCID 0000-0001-5276-7690

Funding

Pacific Northwest Center for Cryo-EM: Equipment SupplementR24GM154185 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI James E Evans, CLAUDIA SUSANA LOPEZ · 2024 to 2026
$21.5M
Dynamic Mechanisms of Membrane Channel Gating by CryoEMR35GM124779 · NIGMS · PORTLAND STATE UNIVERSITY · PI Stephen Loen Reichow · 2017 to 2026
$4.2M
Structure, function and aggregation of lens α-crystallins by CryoEMR01EY030987 · NEI · PORTLAND STATE UNIVERSITY · PI REICHOW, STEPHEN LOEN · 2020 to 2024
$1.8M
Mechanisms of structural plasticity, client interactions, and co-aggregation of the lens ⍺-crystallinsF31EY033226 · NEI · PORTLAND STATE UNIVERSITY · PI MILLER, ADAM PHILLIP · 2022 to 2024
$120k
NEI NIH HHS F31 EY033226NEI NIH HHS R01 EY030987NIGMS NIH HHS R24 GM154185NIGMS NIH HHS R35 GM124779
6 · The paper itself

Abstract

Small heat shock proteins (sHSPs) act as first responders during cellular stress by recognizing and sequestering destabilized proteins (clients), preventing their aggregation and facilitating downstream refolding or degradation

Indexed as

Chaperonecryo-electron microscopy (cryo-EM)proteostasissmall heat shock protein (sHSP)

Identifiers

PMID39677757
PMCPMC11642849

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.