Evidence map›Paper›PMID 39677707›Full record

ArticlebioRxiv : the preprint server for biology2024

Glucose-Sensing ChREBP Protein in the Pathogenesis of Dia-betic Retinopathy.

Christopher R Starr, Assylbek Zhylkibayev, Oleg Gorbatyuk, Alli M Nuotio-Antar, James Mobley, Maria B Grant, Marina Gorbatyuk

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Christopher R StarrUniversity of Alabama at Birmingham, School of Medicine, Department of Ophthalmology.
Assylbek ZhylkibayevWake Forest University, School of Medicine, Department of Biochemistry.
Oleg GorbatyukWake Forest University, School of Medicine, Department of Translational Neuroscience.
Alli M Nuotio-AntarBaylor College of Medicine, Department of Pediatrics.
James MobleyUniversity of Alabama at Birmingham, School of Medicine, Department of Anesthesiology and Perioperative Medicine.
Maria B GrantUniversity of Alabama at Birmingham, School of Medicine, Department of Ophthalmology.
Marina GorbatyukWake Forest University, School of Medicine, Department of Biochemistry.ORCID 0000-0001-9060-856X

Funding

Visual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul Douglas Gamlin · 1985 to 2026
$16.9M
NITRIC OXIDE IN THE PATHOGENESIS OF DIABETIC RETINOPATHYR01EY012601 · NEI · UNIVERSITY OF FLORIDA · PI Julia V Busik, Maria Bartolomeo Grant · 1998 to 2026
$9.6M
ACE2 on gut barrier dysfunction and BRB disruptionR01EY032753 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael Edwin Boulton, Maria Bartolomeo Grant · 2022 to 2026
$1.8M
RXR-based therapy for diabetic retinopathyR01EY035539 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Marina Gorbatyuk, Maria Bartolomeo Grant · 2024 to 2026
$1.7M
NEI NIH HHS P30 EY003039NEI NIH HHS R01 EY012601NEI NIH HHS R01 EY032753NEI NIH HHS R01 EY035539
6 · The paper itself

Abstract

Glucose-sensing ChREBP and MondoA are transcriptional factors involved in lipogenic, inflammatory, and insulin signaling pathways implicated in metabolic disorders; however, limited ocular studies have been conducted on these proteins. We aimed to investigate the potential role of ChREBP in pathogenesis of diabetic retinopathy (DR). We used diabetic human and mouse retinal cryosections analyzed by immunohistochemistry. qRT-PCR was performed to quantify gene expression. To explore the role of ChREBP in rods, we generated caChREBP

Indexed as

ChREBPdiabetic retinopathyMondoAproteomics

Identifiers

PMID39677707
PMCPMC11643094

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.