Evidence map›Paper›PMID 39677689›Full record

ArticlebioRxiv : the preprint server for biology2024

Structural basis for aminoacylation of cellular modified tRNA

Swapnil C Devarkar, Christina R Budding, Chathuri Pathirage, Arundhati Kavoor, Cassandra Herbert, Patrick A Limbach, Karin Musier-Forsyth, Yong Xiong

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Swapnil C DevarkarDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven CT, 06511, USA.ORCID 0000-0002-9271-243X
Christina R BuddingDepartment of Chemistry and Biochemistry, Center for RNA Biology, and Center for Retrovirus Research, Ohio State University, Columbus OH, 43210, USA.
Chathuri PathirageDepartment of Chemistry and Biochemistry, Center for RNA Biology, and Center for Retrovirus Research, Ohio State University, Columbus OH, 43210, USA.ORCID 0000-0003-1527-0882
Arundhati KavoorDepartment of Chemistry and Biochemistry, Center for RNA Biology, and Center for Retrovirus Research, Ohio State University, Columbus OH, 43210, USA.ORCID 0000-0002-4950-968X
Cassandra HerbertRieveschl Laboratories for Mass Spectrometry, Department of Chemistry, University of Cincinnati, Cincinnati OH, 45221, USA.
Patrick A LimbachRieveschl Laboratories for Mass Spectrometry, Department of Chemistry, University of Cincinnati, Cincinnati OH, 45221, USA.ORCID 0000-0003-1526-4546
Karin Musier-ForsythDepartment of Chemistry and Biochemistry, Center for RNA Biology, and Center for Retrovirus Research, Ohio State University, Columbus OH, 43210, USA.
Yong XiongDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven CT, 06511, USA.ORCID 0000-0001-9625-9313

Funding

Translational quality control by tRNA-editing domainsR35GM141880 · NIGMS · OHIO STATE UNIVERSITY · PI Karin M Musier-Forsyth · 2021 to 2026
$2.9M
Cellular, molecular, and biochemical sciences training grantT32GM141955 · NIGMS · OHIO STATE UNIVERSITY · PI Jane Elizabeth Jackman, JESSE J KWIEK · 2021 to 2026
$2.2M
Cellular Factors Critical for Initiation of HIV-1 Reverse TranscriptaseR01AI150493 · NIAID · OHIO STATE UNIVERSITY · PI MUSIER-FORSYTH, KARIN M · 2020 to 2022
$1.2M
Mechanism of selective packaging of primer tRNALys3 by HIV-1R21AI157890 · NIAID · YALE UNIVERSITY · PI MUSIER-FORSYTH, KARIN M, XIONG, YONG · 2021 to 2022
$461k
NIAID NIH HHS R01 AI150493NIAID NIH HHS R21 AI157890NIGMS NIH HHS R35 GM141880NIGMS NIH HHS T32 GM141955
6 · The paper itself

Abstract

The average eukaryotic tRNA contains 13 posttranscriptional modifications; however, their functional impact is largely unknown. Our understanding of the complex tRNA aminoacylation machinery in metazoans also remains limited. Herein, using a series of high-resolution cryo-electron microscopy (cryo-EM) structures, we provide the mechanistic basis for recognition and aminoacylation of fully-modified cellular tRNA

Identifiers

PMID39677689
PMCPMC11643047

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.