Evidence map›Paper›PMID 39677656›Full record

ArticlebioRxiv : the preprint server for biology2024

A CRISPRi Library Screen in Group B

K Firestone, K P Gopalakrishna, L M Rogers, A Peters, J A Gaddy, C Nichols, M H Hall, H N Varela, S M Carlin, G H Hillebrand and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

K FirestoneIndiana University School of Medicine, Department of Medicine.
K P GopalakrishnaCalifornia Institute of Technology, Division of Chemistry and Chemical Engineering, Pasadena, CA, USA.ORCID 0000-0001-6309-1841
L M RogersIndiana University School of Medicine, Department of Medicine.
A PetersUniversity of Pittsburgh, Dietrich School of Arts and Sciences, Pittsburgh, PA, USA.
J A GaddyVanderbilt University Medical Center, Department of Medicine, Nashville, TN, USA.ORCID 0000-0002-2192-4224
C NicholsVanderbilt University Medical Center, Department of Medicine, Nashville, TN, USA.
M H HallDepartment of Veterans Affairs, Tennessee Valley Healthcare Systems, Nashville, TN, USA.
H N VarelaDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
S M CarlinDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0002-7455-5127
G H HillebrandProgram in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0002-3391-4306
E J GiacobeProgram in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0009-0009-8506-011X
D M AronoffIndiana University School of Medicine, Department of Medicine.ORCID 0000-0003-4587-6121
T A HoovenDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0003-1959-186X

Funding

Determining the contribution of zinc deficiency to perinatal Group B Streptococcus infectionsR01HD090061 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ARONOFF, DAVID M, GADDY, JENNIFER A · 2017 to 2021
$2.5M
The Role of macrophages in chorioamnionitis and group B streptococcal infectionsR01AI134036 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ARONOFF, DAVID M · 2017 to 2021
$2.4M
Group B Streptococcus surface determinants of neonatal intestinal colonization and infectionR01AI182835 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thomas A Hooven · 2024 to 2026
$1.6M
Signal transduction, metabolic shifts, and host interactions during group B Streptococcus infectionR01AI177991 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thomas A Hooven · 2024 to 2026
$1.4M
Utility of human milk oligosaccharides against the perinatal pathogen, Group B StreptococcusR01HD113675 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jennifer A Gaddy, Steven D. Townsend · 2024 to 2026
$1.1M
Bacterial CRISPR interference to define macrophage responses to group B Streptococcus proteinsR21AI178067 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ARONOFF, DAVID M, HOOVEN, THOMAS A · 2023 to 2024
$451k
"Research Initiative for Scholar Diversity to Uphold Veteran Health"I01BX007005 · VA · VETERANS HEALTH ADMINISTRATION · PI ALGOOD, HOLLY MARIE SCOTT · 2025 to 2025
–
Toxicant Exposure Impacts Host-pathogen interactions within the Reproductive TractI01BX005352 · VA · VETERANS HEALTH ADMINISTRATION · PI GADDY, JENNIFER A · 2021 to 2024
–
BLRD VA I01 BX005352BLRD VA I01 BX007005NIAID NIH HHS R01 AI134036NIAID NIH HHS R01 AI177991NIAID NIH HHS R01 AI182835NIAID NIH HHS R21 AI178067NICHD NIH HHS R01 HD090061NICHD NIH HHS R01 HD113675
6 · The paper itself

Abstract

Group B

Indexed as

CRISPR interferencecytokine responseGroup B Streptococcushost-pathogen interactionssurface proteins

Identifiers

PMID39677656
PMCPMC11643019

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.