Evidence map›Paper›PMID 39677651›Full record

ArticlebioRxiv : the preprint server for biology2024

Cardiac Applications of CRISPR/AAV-Mediated Precise Genome Editing.

Yanjiang Zheng, Joshua Mayourian, Justin S King, Yifei Li, Vassilios J Bezzerides, William T Pu, Nathan J VanDusen

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yanjiang ZhengKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Joshua MayourianDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Justin S KingDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Yifei LiKey Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China.ORCID 0000-0002-3096-4287
Vassilios J BezzeridesDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
William T PuDepartment of Cardiology, Boston Children's Hospital, Boston, MA, USA.
Nathan J VanDusenDepartment of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-2636-7228

Funding

Regulation of Cardiomyocyte MaturationR01HL146634 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI PU, WILLIAM TSWENCHING · 2019 to 2022
$2.4M
Functional dissection of the regulatory network that governs cardiomyocyte maturation.K99HL143194 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI VANDUSEN, NATHAN JAMES · 2019 to 2021
$232k
NHLBI NIH HHS K99 HL143194NHLBI NIH HHS R01 HL146634
6 · The paper itself

Abstract

The ability to efficiently make precise genome edits in somatic tissues will have profound implications for gene therapy and basic science. CRISPR/Cas9 mediated homology-directed repair (HDR) is one approach that is commonly used to achieve precise and efficient editing in cultured cells. Previously, we developed a platform capable of delivering CRISPR/Cas9 gRNAs and donor templates via adeno-associated virus to induce HDR (CASAAV-HDR). We demonstrated that CASAAV-HDR is capable of creating precise genome edits

Indexed as

EnhancerFunctional GenomicsGenome editingMassively Parallel Reporter AssayPLN-R14DelTruncated Titin

Identifiers

PMID39677651
PMCPMC11642850

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.