Evidence map›Paper›PMID 39677646›Full record

ArticlebioRxiv : the preprint server for biology2025

Functional constraints of

Ananya Nidamangala Srinivasa, Samuel Campbell, Shriram Venkatesan, Nicole L Nuckolls, Jeffrey J Lange, Randal Halfmann, Sarah E Zanders

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ananya Nidamangala SrinivasaStowers Institute for Medical Research, Kansas City, Missouri, United States of America.ORCID 0000-0003-1487-2793
Samuel CampbellStowers Institute for Medical Research, Kansas City, Missouri, United States of America.
Shriram VenkatesanStowers Institute for Medical Research, Kansas City, Missouri, United States of America.ORCID 0000-0003-0778-2474
Nicole L NuckollsStowers Institute for Medical Research, Kansas City, Missouri, United States of America.ORCID 0000-0001-7088-7944
Jeffrey J LangeStowers Institute for Medical Research, Kansas City, Missouri, United States of America.
Randal HalfmannStowers Institute for Medical Research, Kansas City, Missouri, United States of America.ORCID 0000-0002-6592-1471
Sarah E ZandersStowers Institute for Medical Research, Kansas City, Missouri, United States of America.ORCID 0000-0003-1867-986X

Funding

Models of Selfishness: Molecular and Evolutionary Analyses of the Wtf Meiotic DriversDP2GM132936 · NIGMS · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI ZANDERS, SARAH ELIZABETH · 2018 to 2018
$2.5M
Molecular Mechanisms and Evolutionary Impacts of the wtf Meiotic DriversR35GM151982 · NIGMS · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI Sarah Elizabeth Zanders · 2024 to 2026
$1.4M
Investigating the mechanism of wtf killer meiotic driversF31HD097974 · NICHD · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI NUCKOLLS, NICOLE · 2018 to 2020
$49k
NICHD NIH HHS F31 HD097974NIGMS NIH HHS DP2 GM132936NIGMS NIH HHS R35 GM151982
6 · The paper itself

Abstract

Killer meiotic drivers are selfish DNA loci that sabotage the gametes that do not inherit them from a driver+/driver- heterozygote. These drivers often employ toxic proteins that target essential cellular functions to cause the destruction of driver- gametes. Identifying the mechanisms of drivers can expand our understanding of infertility and reveal novel insights about the cellular functions targeted by drivers. In this work, we explore the molecular mechanisms underlying the

Identifiers

PMID39677646
PMCPMC11642804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.