Evidence map›Paper›PMID 39677625›Full record

ArticlebioRxiv : the preprint server for biology2024

ALDH3A1-mediated detoxification of reactive aldehydes contributes to distinct muscle responses to denervation and Amyotrophic Lateral Sclerosis progression.

Ang Li, Li Dong, Xuejun Li, Jianxun Yi, Jianjie Ma, Jingsong Zhou

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Ang LiDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, TX, 76019, USA.ORCID 0000-0002-8784-4702
Li DongDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, TX, 76019, USA.
Xuejun LiDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, TX, 76019, USA.
Jianxun YiDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, TX, 76019, USA.
Jianjie MaDepartment of Surgery, Division of Surgical Sciences, University of Virginia, Charlottesville, VA, 22903, USA.
Jingsong ZhouDepartment of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, TX, 76019, USA.ORCID 0000-0002-5684-7177

Funding

Preserving Mitochondrial Function for Alleviating ALS ProgressionR01NS105621 · NINDS · UNIVERSITY OF TEXAS ARLINGTON · PI BROTTO, MARCO, ZHOU, JINGSONG · 2019 to 2023
$2.9M
Multifaceted role of MG53 in alleviating neuromuscular function decline in ALSR01NS129219 · NINDS · UNIVERSITY OF TEXAS ARLINGTON · PI Jianjie Ma, Lyle Wilfred Ostrow · 2023 to 2026
$2.5M
NINDS NIH HHS R01 NS105621NINDS NIH HHS R01 NS129219
6 · The paper itself

Abstract

Different muscles exhibit varied susceptibility to degeneration in Amyotrophic Lateral Sclerosis (ALS), a fatal neuromuscular disorder. Extraocular muscles (EOMs) are particularly resistant to ALS progression and exploring the underlying molecular nature may deliver great therapeutic value. Reactive aldehyde 4-hydroxynonenal (HNE) is implicated in ALS pathogenesis and ALDH3A1 is an inactivation-resistant intracellular detoxifier of 4-HNE protecting eyes against UV-induced oxidative stress. Here we detected prominently higher levels of

Indexed as

aldehyde dehydrogenaseamyotrophic lateral sclerosisextraocular musclenuclear translocationReactive aldehydessciatic nerve transection

Identifiers

PMID39677625
PMCPMC11642873

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.