Evidence map›Paper›PMID 39677623›Full record

ArticlebioRxiv : the preprint server for biology2025

Approximate Bayesian computation supports a high incidence of chromosomal mosaicism in blastocyst-stage human embryos.

Qingya Yang, Sara A Carioscia, Matthew Isada, Rajiv C McCoy

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Qingya YangDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA 21218.ORCID 0009-0005-9197-0380
Sara A CariosciaDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA 21218.ORCID 0000-0002-0844-615X
Matthew IsadaDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA 21218.ORCID 0000-0003-4355-6407
Rajiv C McCoyDepartment of Biology, Johns Hopkins University, Baltimore, MD, USA 21218.ORCID 0000-0003-0615-146X

Funding

Function and fitness consequences of human genetic variationR35GM133747 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Rajiv Champion McCoy · 2019 to 2026
$3.3M
NIGMS NIH HHS R35 GM133747
6 · The paper itself

Abstract

Chromosome mis-segregation is common in human meiosis and mitosis, and the resulting aneuploidies are the leading cause of pregnancy loss. Preimplantation genetic testing for aneuploidy (PGT-A) prioritizes chromosomally normal embryos for transfer based on analysis of a biopsy of approximately five trophectoderm cells from blastocyst-stage

Indexed as

aneuploidydevelopmentIVFmeiosismitosisPGT-A

Identifiers

PMID39677623
PMCPMC11642757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.