Evidence map›Paper›PMID 39677615›Full record

ArticlebioRxiv : the preprint server for biology2024

In vivo, online label-free monitoring of heterogenous oxygen utilization during phototherapy with real-time ultrasound-guided photoacoustic imaging.

Andrew Langley, Allison Sweeney, Ronak T Shethia, Brooke Bednarke, Faizah Wulandana, Marvin Xavierselvan, Srivalleesha Mallidi

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Andrew LangleyDepartment of Biomedical Engineering, Tufts University, MA, USA.
Allison SweeneyDepartment of Biomedical Engineering, Tufts University, MA, USA.
Ronak T ShethiaDepartment of Biomedical Engineering, Tufts University, MA, USA.
Brooke BednarkeDepartment of Biomedical Engineering, Tufts University, MA, USA.
Faizah WulandanaDepartment of Biomedical Engineering, Tufts University, MA, USA.
Marvin XavierselvanDepartment of Biomedical Engineering, Tufts University, MA, USA.
Srivalleesha MallidiDepartment of Biomedical Engineering, Tufts University, MA, USA.ORCID 0000-0003-1547-1764

Funding

Image-guided oxygen enhanced photodynamic therapy with multi-functional nanodroplets to improve head and neck cancer treatment outcomesR01CA266701 · NCI · TUFTS UNIVERSITY MEDFORD · PI Srivalleesha Mallidi · 2022 to 2026
$1.7M
Biodegradable liquid metal nanoagents for photoacoustic image-guided photodynamic therapyR21CA263694 · NCI · TUFTS UNIVERSITY MEDFORD · PI MALLIDI, SRIVALLEESHA · 2022 to 2023
$399k
NCI NIH HHS R01 CA266701NCI NIH HHS R21 CA263694
6 · The paper itself

Abstract

Understanding the tumor microenvironment, particularly the vascular density and the availability of oxygen, is key in individualizing treatment approaches and determining their efficacy. While there are many therapies including radiotherapy that are ineffective in hypoxic tumor microenvironments, here we demonstrate the heterogeneous oxygen consumption during photodynamic therapy (PDT), a non-invasive treatment method using localized light to activate a photosensitive drug in the presence of oxygen that has shown high effectiveness in the treatment of various types of tumors, including those presented in head and neck cancer (HNC) patients. While our previous work has demonstrated that blood oxygen saturation (StO

Identifiers

PMID39677615
PMCPMC11642742

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.