Evidence map›Paper›PMID 39677598›Full record

ArticlebioRxiv : the preprint server for biology2024

The VGCC auxiliary subunit α2δ1 is an extracellular GluA1 interactor and regulates LTP, spatial memory, and seizure susceptibility.

Gerardo Leana-Sandoval, Ananth V Kolli, Matthew A Sandoval, Emily Saavedra, Kathy H Li, Lulu Y Chen, Alma L Burlingame, Jorge Ramírez-Franco, Javier Díaz-Alonso

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gerardo Leana-SandovalDepartment of Anatomy & Neurobiology, University of California at Irvine, CA, 92617, USA.
Ananth V KolliDepartment of Anatomy & Neurobiology, University of California at Irvine, CA, 92617, USA.
Matthew A SandovalDepartment of Anatomy & Neurobiology, University of California at Irvine, CA, 92617, USA.
Emily SaavedraDepartment of Anatomy & Neurobiology, University of California at Irvine, CA, 92617, USA.
Kathy H LiDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
Lulu Y ChenDepartment of Anatomy & Neurobiology, University of California at Irvine, CA, 92617, USA.
Alma L BurlingameDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA.
Jorge Ramírez-FrancoInstitut de Neurosciences de la Timone, Aix-Marseille Université (AMU) & CNRS, UMR7289, 13005, Marseille, France.
Javier Díaz-AlonsoDepartment of Anatomy & Neurobiology, University of California at Irvine, CA, 92617, USA.ORCID 0000-0002-4980-7441

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Uncover Strategies Used By Biological SystemsP50GM076516 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI NIE, QING · 2007 to 2016
$25.1M
Epilepsy Research Training ProgramT32NS045540 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Tallie Z. Baram, Robert F Hunt · 2003 to 2026
$4.9M
Training Program in Learning and MemoryT32MH119049 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BRUCE L MCNAUGHTON, Manuella Yassa · 2019 to 2026
$1.4M
Novel approaches to study AMPA receptor trafficking and LTPR00MH118425 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI DIAZ ALONSO, JAVIER · 2020 to 2022
$745k
Novel approaches to study AMPA receptor trafficking and LTPK99MH118425 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DIAZ ALONSO, JAVIER · 2018 to 2019
$242k
NCI NIH HHS P30 CA062203NIGMS NIH HHS P50 GM076516NIMH NIH HHS K99 MH118425NIMH NIH HHS R00 MH118425NIMH NIH HHS T32 MH119049NINDS NIH HHS T32 NS045540
6 · The paper itself

Abstract

Activity-dependent synaptic accumulation of AMPA receptors (AMPARs) and subsequent long-term synaptic strengthening underlie different forms of learning and memory. The AMPAR subunit GluA1 amino-terminal domain is essential for synaptic docking of AMPAR during LTP, but the precise mechanisms involved are not fully understood. Using unbiased proteomics, we identified the epilepsy and intellectual disability-associated VGCC auxiliary subunit α2δ1 as a candidate extracellular AMPAR slot. Presynaptic α2δ1 deletion in CA3 affects synaptic AMPAR incorporation during long-term potentiation, but not basal synaptic transmission, at CA1 synapses. Consistently, mice lacking α2δ1 in CA3 display a specific impairment in CA1-dependent spatial memory, but not in memory tests involving other cortical regions. Decreased seizure susceptibility in mice lacking α2δ1 in CA3 suggests a regulation of circuit excitability by α2δ1/AMPAR interactions. Our study sheds light on the regulation of activity-dependent AMPAR trafficking, and highlights the synaptic organizing roles of α2δ1.

Indexed as

AMPAR amino-terminal domainAMPA receptorcacna2d1gabapentinoidshippocampal excitabilitylong-term potentiationobject-location memorytranssynaptic organizationvoltage-gated calcium channel

Identifiers

PMID39677598
PMCPMC11642997

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.