Evidence map›Paper›PMID 39677464›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Alzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset.

Yuk Yee Leung, Wan-Ping Lee, Amanda B Kuzma, Heather Nicaretta, Otto Valladares, Prabhakaran Gangadharan, Liming Qu, Yi Zhao, Youli Ren, Po-Liang Cheng and 35 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

45 authors.

Yuk Yee LeungDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.ORCID 0000-0002-3047-5440
Wan-Ping LeeDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.ORCID 0000-0002-5305-1181
Amanda B KuzmaDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Heather NicarettaDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Otto ValladaresDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Prabhakaran GangadharanDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Liming QuDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Yi ZhaoDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Youli RenDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Po-Liang ChengDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Pavel P KuksaDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Hui WangDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Heather WhiteDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Zivadin KatanicDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Lauren BassDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Naveen SaravananDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Emily Greenfest-AllenDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Maureen KirschDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Laura CantwellDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Taha IqbalDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Nicholas R WheelerDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
John J FarrellDepartment of Medicine, Biostatistics & Bioinformatics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Congcong ZhuDepartment of Medicine, Biostatistics & Bioinformatics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Shannon L TurnerDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Tamil I GunasekaranColumbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-8639-5060
Pedro R MenaDepartment of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Jimmy JinDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Luke CarterDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Alzheimer’s Disease Sequencing Project
Xiaoling ZhangDepartment of Medicine, Biostatistics & Bioinformatics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.ORCID 0000-0001-8237-1857
Badri N VardarajanColumbia University Irving Medical Center, New York, NY, USA.
Arthur TogaLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California.ORCID 0000-0001-7902-3755
Michael CuccaroDepartment of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Timothy J HohmanDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-3377-7014
William S BushDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0002-9729-6519
Adam C NajDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.ORCID 0000-0002-9621-2942
Eden MartinDepartment of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Clifton DalgardDepartment of Anatomy, Physiology and Genetics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.ORCID 0000-0003-2025-8239
Brian W KunkleDepartment of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Lindsay A FarrerDepartment of Medicine, Biostatistics & Bioinformatics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Richard P MayeuxColumbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-6519-9696
Jonathan L HainesDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
Margaret A Pericak-VanceDepartment of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Gerard D SchellenbergDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.
Li-San WangDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania.

Funding

Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6M
Large Scale Genome SequencingU54HG003079 · NHGRI · WASHINGTON UNIVERSITY · PI DUTCHER, SUSAN K · 2004 to 2016
$445.7M
The Human Genome Sequencing CenterU54HG003273 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2004 to 2015
$341.3M
Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI ARTHUR W TOGA · 2016 to 2026
$226.7M
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI Christine L MacDonald · 2021 to 2026
$80.4M
Vascular Structure and Function in Cognitive AgingP01AG003949 · NIA · YESHIVA UNIVERSITY · PI CHRISTOPHER G ENGELAND · 1985 to 2026
$73.9M
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
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6 · The paper itself

Abstract

The Alzheimer's Disease Sequencing Project (ADSP) is a national initiative to understand the genetic architecture of Alzheimer's Disease and Related Dementias (AD/ADRD) by sequencing whole genomes of affected participants and age-matched cognitive controls from diverse populations. The Genome Center for Alzheimer's Disease (GCAD) processed whole-genome sequencing data from 36,361 ADSP participants, including 35,014 genetically unique participants of which 45% are from non-European ancestry, across 17 cohorts in 14 countries in this fourth release (R4). This sequencing effort identified 387 million bi-allelic variants, 42 million short insertions/deletions, and 2.2 million structural variants. Annotations and quality control data are available for all variants and samples. Additionally, detailed phenotypes from 15,927 participants across 10 domains are also provided. A linkage disequilibrium panel was created using unrelated AD cases and controls. Researchers can access and analyze the genetic data via NIAGADS Data Sharing Service, the VariXam tool, or NIAGADS GenomicsDB.

Identifiers

PMID39677464
PMCPMC11643159

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