Evidence map›Paper›PMID 39677452›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Genetic Analysis of Psychosis Biotypes: Shared Ancestry-Adjusted Polygenic Risk and Unique Genomic Associations.

Cuihua Xia, Ney Alliey-Rodriguez, Carol A Tamminga, Matcheri S Keshavan, Godfrey D Pearlson, Sarah K Keedy, Brett Clementz, Jennifer E McDowell, David Parker, Rebekka Lencer and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Cuihua XiaMOE Key Laboratory of Rare Pediatric Diseases & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, and Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha 410000, China.ORCID 0000-0002-6915-3385
Ney Alliey-RodriguezDepartment of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL 60637, USA.
Carol A TammingaDepartment of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Matcheri S KeshavanDepartment of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Godfrey D PearlsonDepartments of Psychiatry and Neuroscience, Yale University School of Medicine, New Haven, CT 06511, USA.
Sarah K KeedyDepartment of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL 60637, USA.
Brett ClementzDepartments of Psychology and Neuroscience, BioImaging Research Center, University of Georgia, Athens, GA 30602, USA.
Jennifer E McDowellDepartments of Psychology and Neuroscience, BioImaging Research Center, University of Georgia, Athens, GA 30602, USA.
David ParkerDepartments of Psychology and Neuroscience, BioImaging Research Center, University of Georgia, Athens, GA 30602, USA.
Rebekka LencerInstitute for Translational Psychiatry, Münster University, Münster 48149, Germany.
S Kristian HillDepartment of Psychology, Rosalind Franklin University of Medicine and Science, Chicago, IL 60064, USA.
Jeffrey R BishopDepartment of Experimental and Clinical Pharmacology and Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN 55455, USA.
Elena I IvlevaDepartment of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390, USA.
Cindy WenInterdepartmental Program in Bioinformatics, University of California, Los Angeles; Los Angeles, CA 90095, USA.ORCID 0000-0001-8747-8231
Rujia DaiDepartment of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA.ORCID 0000-0002-9979-3295
Chao ChenMOE Key Laboratory of Rare Pediatric Diseases & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, and Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha 410000, China.ORCID 0000-0002-5114-2282
Chunyu LiuMOE Key Laboratory of Rare Pediatric Diseases & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, and Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha 410000, China.ORCID 0000-0002-5986-4415
Elliot S GershonDepartment of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-4818-8631

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
J: NRSA Training CoreTL1TR002382 · NCATS · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Vasiliki Michopoulos · 2017 to 2026
$8.5M
Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077851 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI TAMMINGA, CAROL A · 2007 to 2019
$7.8M
Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077945 · NIMH · YALE UNIVERSITY · PI PEARLSON, GODFREY D · 2007 to 2019
$7.6M
Stability of Biotypes: a Longitudinal EvaluationR01MH078113 · NIMH · WAYNE STATE UNIVERSITY · PI KESHAVAN, MATCHERI S. · 2007 to 2019
$6.2M
Stability of Biotypes: a Longitudinal Evaluation (STABLE)R01MH103368 · NIMH · UNIVERSITY OF CHICAGO · PI GERSHON, ELLIOT S, KEEDY, SARAH K · 2015 to 2019
$4.5M
2/2-Discovery and validation of neuronal enhancers associated with the development of psychiatric disordersU01MH116489 · NIMH · UNIVERSITY OF CHICAGO · PI GAYNOR, SOPHIA, GESCHWIND, DANIEL H · 2018 to 2022
$4.5M
5/5 BIPOLAR-SCHIZOPHRENIA NETWORK FOR INTERMEDIATE PHENOTYPES (B-SNIP) - Resubmission - 1R01MH103366 · NIMH · UNIVERSITY OF GEORGIA · PI CLEMENTZ, BRETT A, GIBBONS, ROBERT D · 2015 to 2019
$3.8M
Gene Expression Regulation in Brains of East Asian, African, and European Descent Explains Schizophrenia GWAS in Diverse Populations.R01MH126459 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI Chunyu Liu · 2022 to 2026
$3.7M
Psychosis-related Physiological and Neuronal Phenotypes in 22q11 Deletion SyndromeR01MH117315 · NIMH · EMORY UNIVERSITY · PI CUBELLS, JOSEPH F., DUNCAN, ERICA J · 2019 to 2023
$3.4M
1/2 Measuring translational dynamics and the proteome to identify potential brain biomarkers for psychiatric diseaseR01MH110920 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI LIU, CHUNYU · 2016 to 2019
$2.0M
2/5-Clozapine Response and Biomarker Correlates in Low-IEA Biotype-1R01MH124804 · NIMH · UNIVERSITY OF CHICAGO · PI GERSHON, ELLIOT S, KEEDY, SARAH K · 2021 to 2025
$1.8M
NCATS NIH HHS TL1 TR002382NCATS NIH HHS UL1 TR002378NIMH NIH HHS R01 MH077851NIMH NIH HHS R01 MH077945NIMH NIH HHS R01 MH078113NIMH NIH HHS R01 MH096900NIMH NIH HHS R01 MH096913NIMH NIH HHS R01 MH096942NIMH NIH HHS R01 MH096957NIMH NIH HHS R01 MH103366NIMH NIH HHS R01 MH103368NIMH NIH HHS R01 MH110920NIMH NIH HHS R01 MH117315NIMH NIH HHS R01 MH124802NIMH NIH HHS R01 MH124803NIMH NIH HHS R01 MH124804NIMH NIH HHS R01 MH124806NIMH NIH HHS R01 MH126459NIMH NIH HHS R01 MH127162NIMH NIH HHS R01 MH127172NIMH NIH HHS R21 MH126398NIMH NIH HHS U01 MH116489NIMH NIH HHS U01 MH122591
6 · The paper itself

Abstract

The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) created psychosis Biotypes based on neurobiological measurements in a multi-ancestry sample. These Biotypes cut across DSM diagnoses of schizophrenia, schizoaffective disorder and bipolar disorder with psychosis. Two recently developed

Identifiers

PMID39677452
PMCPMC11643284

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.