Evidence map›Paper›PMID 39677434›Full record

ArticlemedRxiv : the preprint server for health sciences2024

The striatum is an early, accurate indicator of amyloid burden using [

Max McLachlan, Brecca Bettcher, Andrew McVea, Alexandra DiFillipo, Matthew Zammit, Lisette LeMerise, Jeremy Rouanet, Julie Price, Dana Tudorascu, Charles Laymon and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Max McLachlanUniversity of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0003-1801-7233
Brecca BettcherUniversity of Wisconsin-Madison, Madison, WI, USA.
Andrew McVeaUniversity of Wisconsin-Madison, Madison, WI, USA.
Alexandra DiFillipoUniversity of Wisconsin-Madison, Madison, WI, USA.
Matthew ZammitUniversity of Wisconsin-Madison, Madison, WI, USA.
Lisette LeMeriseUniversity of Wisconsin-Madison, Madison, WI, USA.
Jeremy RouanetUniversity of California, Irvine, Irvine, CA, USA.
Julie PriceMGH Martinos Center, Harvard, Boston, MA, USA.
Dana TudorascuUniversity of Pittsburgh, Pittsburgh, PA, USA.
Charles LaymonUniversity of Pittsburgh, Pittsburgh, PA, USA.
David KeatorUniversity of California, Irvine, Irvine, CA, USA.
Patrick LaoVagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Adam M BrickmanVagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Tim FryerUniversity of Cambridge, Cambridge, UK.
Sigan HartleyUniversity of Wisconsin-Madison, Madison, WI, USA.
Beau M AncesWashington University in St. Louis, St. Louis, MO, USA.
Sterling JohnsonUniversity of Wisconsin-Madison, Madison, WI, USA.
Tobey BetthauserUniversity of Wisconsin-Madison, Madison, WI, USA.
Charles K StoneUniversity of Wisconsin-Madison, Madison, WI, USA.
Shahid ZamanUniversity of Cambridge, Cambridge, UK.
Benjamin HandenUniversity of Pittsburgh, Pittsburgh, PA, USA.
Elizabeth HeadUniversity of California, Irvine, Irvine, CA, USA.
Mark MapstoneUniversity of California, Irvine, Irvine, CA, USA.
Bradley T ChristianUniversity of Wisconsin-Madison, Madison, WI, USA.

Funding

Project 3: Biomarkers for DS Clinical TrialsU19AG068054 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTIAN, BRADLEY T, HANDEN, BENJAMIN L · 2020 to 2025
$103.7M
TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SWEET, ROBERT A · 1985 to 2019
$43.0M
Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sanjay Asthana · 2019 to 2026
$34.5M
Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHILIP L DE JAGER · 2020 to 2026
$30.1M
NiAD Supplement WashU Start UpU01AG051406 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANDEN, BENJAMIN L, TOGA, ARTHUR W · 2015 to 2019
$21.3M
Roles of Gray Matter Brain Aging and Small Vessel Disease in AD PathophysiologyRF1AG025516 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AIZENSTEIN, HOWARD J, VILLEMAGNE, VICTOR LUIS · 2014 to 2021
$9.0M
Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Qiang Chang · 2021 to 2026
$8.5M
Natural History of Amyloid Deposition in Adults with Down SyndromeR01AG031110 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANDEN, BENJAMIN L · 2009 to 2016
$5.2M
NIA NIH HHS P30 AG062715NIA NIH HHS P30 AG066462NIA NIH HHS P50 AG005133NIA NIH HHS R01 AG031110NIA NIH HHS RF1 AG025516NIA NIH HHS U01 AG051406NIA NIH HHS U19 AG068054NICHD NIH HHS P50 HD105353
6 · The paper itself

Abstract

introductionAdults with Down syndrome demonstrate striatum-first amyloid accumulation with [

methodsLongitudinal PiB (n=175 participants) and FBP (n=92 participants) data from the Alzheimer Biomarkers Consortium-Down Syndrome were used to measure cortical and striatal binding. Generalized temporal models for cortical and striatal amyloid accumulation were created using the sampled iterative local approximation (SILA) method.

resultsPiB demonstrated greater striatal-to-cortical ratios than FBP. SILA analysis revealed striatal amyloid burden occurs 3.40 (2.39) years earlier than the cortex in PiB. There was no difference between the cortex and striatum in FBP. DISCUSSION: Among adults with Down syndrome, the striatum consistently accumulates amyloid earlier than the cortex when measured with PiB. This suggests the striatum is more sensitive to the onset of PiB PET-detectable amyloid in Down syndrome.

Identifiers

PMID39677434
PMCPMC11643166

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.