Evidence map›Paper›PMID 39677432›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Peritraumatic C-reactive protein levels predict pain outcomes following traumatic stress exposure in a sex-dependent manner.

Lauren A McKibben, Miranda N Layne, Liz Marie Albertorio-Sáez, Ying Zhao, Erica M Branham, Stacey L House, Francesca L Beaudoin, Xinming An, Jennifer S Stevens, Thomas C Neylan and 31 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

41 authors.

Lauren A McKibbenInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.ORCID 0000-0002-7307-6677
Miranda N LayneInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.ORCID 0009-0000-9233-4910
Liz Marie Albertorio-SáezInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.ORCID 0000-0003-3419-5849
Ying ZhaoInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.ORCID 0009-0001-7060-6679
Erica M BranhamInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.ORCID 0000-0003-2504-6067
Stacey L HouseDepartment of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.ORCID 0000-0003-1161-4529
Francesca L BeaudoinDepartment of Epidemiology, Brown University, Providence, RI, 02930, USA.ORCID 0000-0002-0462-019X
Xinming AnInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.ORCID 0000-0002-8332-0362
Jennifer S StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30329, USA.ORCID 0000-0003-4674-0314
Thomas C NeylanDepartments of Psychiatry and Neurology, University of California San Francisco, San Francisco, CA, 94143, USA.ORCID 0000-0002-1572-2626
Gari D CliffordDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, 30332, USA.
Laura T GermineInstitute for Technology in Psychiatry, McLean Hospital, Belmont, MA, 02478, USA.ORCID 0000-0001-8690-8412
Kenneth A BollenDepartment of Psychology and Neuroscience & Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.ORCID 0000-0002-6710-3800
Scott L RauchInstitute for Technology in Psychiatry, McLean Hospital, Belmont, MA, 02478, USA.ORCID 0000-0001-7699-6754
John P HaranDepartment of Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01655, USA.ORCID 0000-0001-7311-1121
Alan B StorrowDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.ORCID 0000-0002-2893-808X
Christopher LewandowskiDepartment of Emergency Medicine, Henry Ford Health System, Detroit, MI, 48202, USA.ORCID 0000-0001-8297-0024
Paul I MuseyDepartment of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.ORCID 0000-0002-5693-190X
Phyllis L HendryDepartment of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, 32209, USA.ORCID 0000-0002-4881-5159
Sophia SheikhDepartment of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, 32209, USA.ORCID 0000-0003-1939-3126
Christopher W JonesDepartment of Emergency Medicine, Cooper Medical School of Rowan University, Camden, NJ, 08103, USA.ORCID 0009-0002-6383-7177
Brittany E PunchesDepartment of Emergency Medicine, Ohio State University College of Medicine, Columbus, OH, 43210, USA.ORCID 0000-0002-7546-1966
Robert A SworDepartment of Emergency Medicine, Oakland University William Beaumont School of Medicine, Rochester, MI, 48309, USA.
Lauren A HudakDepartment of Emergency Medicine, Emory University School of Medicine, Atlanta, GA, 30329, USA.
Jose L PascualDepartment of Surgery, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID 0000-0002-1613-7912
Mark J SeamonDepartment of Surgery, Division of Traumatology, Surgical Critical Care and Emergency Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID 0000-0001-7536-5467
Elizabeth M DatnerDepartment of Emergency Medicine, Jefferson Einstein hospital, Jefferson Health, Philadelphia, PA, 19141, USA.
David A PeakDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Roland C MerchantDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.ORCID 0000-0001-7571-1294
Robert M DomeierDepartment of Emergency Medicine, Trinity Health-Ann Arbor, Ypsilanti, MI, 48197, USA.ORCID 0000-0002-4990-9165
Niels K RathlevDepartment of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, MA, 01107, USA.ORCID 0000-0002-6126-9201
Brian J O'NeilDepartment of Emergency Medicine, Wayne State University, Detroit Receiving Hospital, Detroit, MI, 48202, USA.
Leon D SanchezDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Steven E BruceDepartment of Psychological Sciences, University of Missouri - St. Louis, St. Louis, MO, 63121, USA.
John F SheridanDivision of Biosciences, Ohio State University College of Dentistry, Columbus, OH, 43210, USA.ORCID 0000-0002-6927-0266
Steven E HarteDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-2929-8694
Ronald C KesslerDepartment of Health Care Policy, Harvard Medical School, Boston, MA, 02115, USA.ORCID 0000-0003-4831-2305
Karestan C KoenenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, 02115, USA.ORCID 0000-0003-2978-7655
Kerry J ResslerDivision of Depression and Anxiety, McLean Hospital, Belmont, MA, 02478, USA.ORCID 0000-0002-5158-1103
Samuel A McLeanDepartment of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.ORCID 0000-0001-9482-3582
Sarah D LinnstaedtInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.ORCID 0000-0001-5295-7072

Funding

Longitudinal Assessment of Post-traumatic SyndromesU01MH110925 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESSLER, RONALD C, KOENEN, KARESTAN C · 2016 to 2020
$25.8M
Mobile Measures of Threat Sensitivity for Cross-sectional and Longitudinal AssessmentR01MH121617 · NIMH · MCLEAN HOSPITAL · PI GERMINE, LAURA THI · 2020 to 2025
$3.9M
TRAUMA RESEARCH FELLOWSHIPT32GM008450 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Bruce A Cairns, Anthony G Charles · 1992 to 2026
$3.8M
FKBP51 antagonism to prevent chronic pain: optimizing efficacy & evaluating safety and mechanismsR01NS118563 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LINNSTAEDT, SARAH, MCLEAN, SAMUEL A. · 2020 to 2024
$3.4M
Sex-dependent microRNA-mediated pathways to chronic musculoskeletal pain following traumaR01AR081454 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LINNSTAEDT, SARAH · 2024 to 2025
$950k
Key Molecular Mechanisms of Chronic Pain Vulnerability in Women Experiencing MVCK01AR071504 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LINNSTAEDT, SARAH · 2018 to 2021
$502k
NIAMS NIH HHS K01 AR071504NIAMS NIH HHS R01 AR081454NIGMS NIH HHS T32 GM008450NIMH NIH HHS R01 MH121617NIMH NIH HHS U01 MH110925NINDS NIH HHS R01 NS118563
6 · The paper itself

Abstract

Background: Chronic pain following traumatic stress exposure (TSE) is common. Increasing evidence suggests inflammatory/immune mechanisms are induced by TSE, play a key role in the recovery process versus development of post-TSE chronic pain, and are sex specific. In this study, we tested the hypothesis that the inflammatory marker C-reactive protein (CRP) is associated with chronic pain after TSE in a sex-specific manner. Methods: We utilized blood-plasma samples and pain questionnaire data from men (n=99) and (n=223) women enrolled in Results: Peritraumatic CRP levels significantly predicted post-TSE chronic pain, such that higher levels of CRP were associated with lower levels of pain over time following TSE, but only in men (men:β=-0.24, Conclusions: In men but not women, we found circulating peritraumatic CRP levels predict chronic pain outcomes following TSE and resolution of CRP levels in men over time might be associated with increased pain recovery. Further studies are needed to validate these results.

Indexed as

adverse posttraumatic neuropsychiatric sequelae (APNS)chronic painC-reactive protein (CRP)posttraumatic stress symptoms (PTSS) and chronic musculoskeletal painsex differencestraumatic stress

Identifiers

PMID39677432
PMCPMC11643190

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