ArticlemedRxiv : the preprint server for health sciences2024
Adherence to Life's Essential 8 is associated with delayed white matter aging.
Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Importance: The American Heart Association introduced Life's Essential 8 (LE8) as a checklist of healthy lifestyle factors to help older individuals maintain and improve cardiovascular health and live longer. How LE8 can foster healthy brain aging and interact with genetic risk factors to render the aging brain less vulnerable to dementia is not well understood. Objective: To investigate the impact of LE8 on the white matter brain aging and the moderating effects of the Design Setting and Participants: This cross-sectional study uses genetic, imaging, and other health-related data collected in the UK Biobank cohort. Participants included non-pregnant whites with LE8 variables, diffusion tensor imaging data, and genetic data on Exposures: LE8 variables, encompassing diet, physical activity, smoking, sleep, body mass index, lipids, hemoglobin, and blood pressure. Main Outcomes and Measures: The white matter brain age was predicted from regional fractional anisotropy measures derived from diffusion tensor imaging data using the random forest regression method. The outcome white matter brain age gap was calculated by subtracting individuals' chronological age from their predicted brain age. Results: The analysis included 9,430 women and 9,387 men (mean age 55.45 [SD: 7.46] years). Higher LE8 scores were associated with lower white matter brain age gap, indicating delayed brain aging. The findings are consistent for each of the individual LE8 variables. The effect was stronger among non- Conclusions and Relevance: Adherence to LE8 is associated with delayed brain aging, moderated by genetic factors such as
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