ArticleCureus2024
Evaluation of Antimicrobial Peptides in Saliva as Potential Therapeutic Agents Against Oral Pathogens in Pakistan.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundMaintaining optimal oral health is essential for overall well-being; however, conditions such as dental caries and gingivitis remain prevalent in Pakistan and are further worsened by increasing antibiotic resistance.
objectiveTo evaluate the antimicrobial properties of salivary peptides as potential therapeutic agents against common oral pathogens in Pakistan. METHODOLOGY: A one-year cross-sectional study was conducted in Lahore, Pakistan, at Sharif Medical and Dental College and Akhter Saeed Medical and Dental College, involving 384 participants aged 18-65 years. High-performance liquid chromatography (HPLC) was used to isolate antimicrobial peptides (AMPs) from oral swabs and saliva samples. Using the enzyme-linked immunosorbent test (ELISA), the minimum inhibitory concentration (MIC) of histatin, defensin, and cathelicidin against
resultsThere were 210 men (54.69%) and 174 women (45.31%) in the participation group. A total of 298 individuals (77.60%) did not smoke, while 221 participants (57.56%) said they brushed their teeth every day. Moreover, 198 individuals (51.56%) had oral infections with
conclusionSalivary AMPs, particularly histatin, defensin, and cathelicidin, demonstrate strong potential as therapeutic alternatives against oral infections such as dental caries and gingivitis, suggesting a promising strategy to mitigate antibiotic resistance in Pakistan. Further research is needed to explore their application in clinical practice.
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