Evidence map›Paper›PMID 39676976›Full record

ArticleACS omega2024

Cholic-Acid Derived, Guanidine-Functionalized Polymers as Broad-Spectrum Antimicrobial Agents.

Yijun Xiong, Umeka Nayanathara, Xiangfeng Lai, Xiangyi Huang, Changhe Zhang, Daniel Yuen, Parveen Sangwan, Hsin-Hui Shen, Angus P R Johnston, Benjamin W Muir and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yijun XiongSchool of Chemistry, The University of Melbourne, Parkville, Victoria 3010, Australia.
Umeka NayanatharaSchool of Chemistry, The University of Melbourne, Parkville, Victoria 3010, Australia.ORCID https://orcid.org/0000-0002-4872-9736
Xiangfeng LaiDepartment of Materials Science and Engineering, Monash University, Clayton, Victoria 3800, Australia.
Xiangyi HuangDepartment of Materials Science and Engineering, Monash University, Clayton, Victoria 3800, Australia.
Changhe ZhangSchool of Chemistry, The University of Melbourne, Parkville, Victoria 3010, Australia.
Daniel YuenDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Parveen SangwanManufacturing, CSIRO, Clayton, Victoria 3168, Australia.
Hsin-Hui ShenDepartment of Materials Science and Engineering, Monash University, Clayton, Victoria 3800, Australia.ORCID https://orcid.org/0000-0002-8541-4370
Angus P R JohnstonDrug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.ORCID https://orcid.org/0000-0001-5611-4515
Benjamin W MuirManufacturing, CSIRO, Clayton, Victoria 3168, Australia.
Georgina K SuchSchool of Chemistry, The University of Melbourne, Parkville, Victoria 3010, Australia.ORCID https://orcid.org/0000-0002-2868-5799

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we report the design of a new guanylated, cholic-acid-based monomer (GM) to combat antimicrobial resistance. The microbial activity stems from the interfacial amphiphilicity of cholic acid, while guanidine shows a strong association with phosphate, which promotes binding to membrane phospholipids. The monomer showed strong antimicrobial activity; however, surprisingly, homopolymers synthesized by photoiniferter reversible addition-fragmentation chain-transfer (RAFT) polymerization of GM completely lost their activity likely due to the conformation of the polymer. In contrast, the design of GM copolymers with poly(ethylene glycol) methyl ether methacrylate (PEGMA) or 2-hydroxyethyl methacrylate (HEMA) allowed recovery of their antimicrobial activity. Due to the existence of cholesterol in cell membranes, hemolysis was highly dependent on the content of GM incorporated. This study highlights the unique and intriguing properties of this novel amphiphilic monomer and its polymers, providing valuable insights into the development of more potent antimicrobial materials.

Identifiers

PMID39676976
PMCPMC11635482

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.