Evidence map›Paper›PMID 39676942›Full record

ArticleACS omega2024

Unraveling the Nanomechanical and Vibrational Properties of the Mayaro Virus.

Alefe Roger Silva França, Joel Félix Silva Diniz-Filho, Clenilton Costa Dos Santos, Laís Durço Coimbra, Rafael Elias Marques, Leandro R S Barbosa, Ralph Santos-Oliveira, Pedro Filho Noronha Souza, Luciana Magalhães Rebelo Alencar

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In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alefe Roger Silva FrançaPhysics Department, Laboratory of Biophysics and Nanosystems, Federal University of Maranhão, São Luís, MA 65085-580, Brazil.ORCID https://orcid.org/0009-0004-1802-3558
Joel Félix Silva Diniz-FilhoPhysics Department, Laboratory of Biophysics and Nanosystems, Federal University of Maranhão, São Luís, MA 65085-580, Brazil.ORCID https://orcid.org/0000-0001-7525-2403
Clenilton Costa Dos SantosPhysics Department, Laboratory of Biophysics and Nanosystems, Federal University of Maranhão, São Luís, MA 65085-580, Brazil.
Laís Durço CoimbraBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-970, Brazil.
Rafael Elias MarquesBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-970, Brazil.
Leandro R S BarbosaInstitute of Physics, University of São Paulo, São Paulo, SP 05508-090, Brazil.ORCID https://orcid.org/0000-0001-5997-2160
Ralph Santos-OliveiraBrazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmacy and Synthesis of New Radiopharmaceuticals, Rio de Janeiro, RJ 21941906, Brazil.ORCID https://orcid.org/0000-0002-0905-481X
Pedro Filho Noronha SouzaDrug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE 60356-150, Brazil.ORCID https://orcid.org/0000-0003-2524-4434
Luciana Magalhães Rebelo AlencarPhysics Department, Laboratory of Biophysics and Nanosystems, Federal University of Maranhão, São Luís, MA 65085-580, Brazil.ORCID https://orcid.org/0000-0001-8210-2016

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mayaro virus (MAYV) is an emerging mosquito-borne viral pathogen whose infection results in arthritogenic disease. Despite ongoing research efforts, MAYV biology is largely unknown. Physical virology can assess MAYV nanoparticle metastability, assembly/disassembly, and polymorphism, allowing us to understand virion architecture and dynamics. Here, we employ atomic force microscopy (AFM) and surface enhancement Raman spectroscopy (SERS) to assess MAYV nanomechanical properties, including maps of adhesion force and Young's modulus on individual viral particles. We established topographic maps of MAYV in two and three dimensions, revealing the three-dimensional arrangement and distribution of charges on viral spikes at the virus surface. Furthermore, the organization of the densely packaged RNA, which affords the viral particle exceptional mechanical resistance compared to chikungunya (CHIKV), was observed using MAYV adsorption patterns. The vibrational signature of MAYV particles differs from CHIKV, with more intense protein modes matching the distribution of E1/E2 dimers and the nucleocapsid, which are well structured and suggestive of mechanical strength.

Identifiers

PMID39676942
PMCPMC11635520

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.