Evidence map›Paper›PMID 39676704›Full record

ArticleInternational journal of experimental pathology2025

Perinatal exposure to lead alters male reproductive behaviour and immunoreactivity of androgen and oestrogen receptors in the brain.

Marcela Arteaga-Silva, Rosa María Vigueras-Villaseñor, Gustavo Guillen-Herrera, Daniel Adrian Landero-Huerta, Itzel Jatziri Contreras-García, Sergio Montes, Camilo Ríos, Ofelia Limón-Morales, Julio César Rojas-Castañeda

Abstract read
In one paragraph

Article in International journal of experimental pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marcela Arteaga-SilvaDepartamento de Biología de la Reproducción, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, Mexico.
Rosa María Vigueras-VillaseñorLaboratorio de Biología de la Reproducción, Instituto Nacional de Pediatría, Ciudad de México, Mexico.ORCID 0000-0003-0187-1994
Gustavo Guillen-HerreraDepartamento de Biología de la Reproducción, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, Mexico.
Daniel Adrian Landero-HuertaLaboratorio de Biología de la Reproducción, Instituto Nacional de Pediatría, Ciudad de México, Mexico.ORCID 0000-0001-9226-7412
Itzel Jatziri Contreras-GarcíaLaboratorio de Biología de la Reproducción, Instituto Nacional de Pediatría, Ciudad de México, Mexico.ORCID 0000-0002-4648-3699
Sergio MontesDepartamento de Farmacología, Unidad Académica Multidisciplinaria Reynos-Aztlan Reynosa, Universidad Autónoma de Tamaulipas, Reynosa, Tamaulipas, Mexico.
Camilo RíosInstituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, Mexico.
Ofelia Limón-MoralesDepartamento de Biología de la Reproducción, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, Mexico.
Julio César Rojas-CastañedaLaboratorio de Biología de la Reproducción, Instituto Nacional de Pediatría, Ciudad de México, Mexico.ORCID 0000-0002-7988-2231

Funding

Instituto Nacional de Pediatria
6 · The paper itself

Abstract

Lead (Pb) exposure during perinatal development alters testosterone (T) concentrations and delays puberty in children and laboratory rodents. In addition, exposure to the metal during adult life decreases T and libido in men and affects male reproductive behaviour (MRB) in rats. MRB is regulated by various brain nuclei including the medial preoptic area (MPOa) and the medial amygdala (MeA), in which T and oestradiol (E

Indexed as

LeadPrenatal Exposure Delayed EffectsPreoptic AreaRats, WistarReceptors, AndrogenTestosteroneAmygdalaAnimalsBrainEstradiolEstrogen Receptor alphaFemaleMalePregnancyRatsReceptors, EstrogenEstradiolEstrogen Receptor alphaLeadReceptors, AndrogenReceptors, EstrogenTestosteroneandrogen receptorLeadmale sexual behaviourmedial amygdalamedial preoptic areaoestrogen receptor α

Identifiers

PMID39676704
PMCPMC11730980

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.