ArticleAnaesthesia2025
Total intravenous or inhalational volatile anaesthesia and survival after colorectal cancer surgery: a Swedish national registry study.
Article in Anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Anaesthetic Type and Survival in Metastatic Colorectal Cancer: A Nationwide Registry Study.Acta anaesthesiologica Scandinavica · 2026Article
- Propofol-based versus volatile anesthesia and postoperative immune response in prostate cancer.Translational andrology and urology · 2026Article
- Propofol-based total intravenous anesthesia and recurrence-free survival after hepatectomy-does it improve outcomes?Annals of translational medicine · 2026Article
- Perioperative Management of a Patient with Good Syndrome and Pancytopenia Undergoing Sternotomy and Thymectomy.Annals of cardiac anaesthesia · 2026Article
- Comparison of total intravenous anesthesia and combined inhalation and intravenous anesthesia on survival after tumor surgery: a propensity score matched cohort study.Frontiers in medicine · 2026Article
- Impact of pediatric anesthesia management on cancer outcomes in children-a narrative review.Frontiers in oncology · 2025Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRetrospective studies suggest that inhalational volatile anaesthetic agents may contribute to an increased risk of metastasis and reduction in survival rates when used during cancer surgery. This relationship may vary between cancer types due to different tumour biology and differences in surgical procedures. This study aimed to investigate the relationship between the type of anaesthetic used for maintenance of anaesthesia (propofol or inhalational volatile anaesthetic agent) and survival in patients with stage 1-3 colorectal cancer who underwent resection surgery under general anaesthesia in Sweden between 2014 and 2019.
methodsWe identified patients from the Swedish Colorectal Cancer Registry. Their data, including cancer characteristics and adjuvant treatment, were then merged with information from the Swedish Peri-operative Registry. The primary outcome was overall survival, with disease-free survival as a secondary outcome.
resultsOf the 11,598 patients included, 8161 had colon cancer and 3437 had rectal cancer. General anaesthesia was maintained with propofol in 2346 (20%) patients, while 9252 (80%) received an inhalational volatile anaesthetic agent. In the unmatched cohort, patients who had general anaesthesia maintained with propofol for colon cancer surgery showed improved survival compared with those receiving an inhalational volatile anaesthetic agent (hazard ratio 0.83, 95%CI 0.72-0.95, p = 0.008). After 1:2 propensity score matching, we observed no significant difference in survival rates in this group (hazard ratio 0.89, 95%CI 0.76-1.04, p = 0.127). In the rectal cancer group, there was no difference in survival in either the unmatched cohort (hazard ratio 0.83, 95%CI 0.65-1.08, p = 0.166) or after propensity score matching (hazard ratio 0.95, 95%CI 0.71-1.25, p = 0.702). There was no significant difference in disease-free survival in either type of cancer. DISCUSSION: We found no association between the choice of agent for maintenance of anaesthesia and long-term survival outcomes in patients with colorectal cancer.
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