Evidence map›Paper›PMID 39676516›Full record

ArticleCancer communications (London, England)2025

Neoadjuvant HER2 inhibition induces ESR1 DNA methylation alterations resulting in clinically relevant ER expression changes in breast cancers.

Gavin P Dowling, Gordon R Daly, Aisling Hegarty, Michael Flanagan, Mihaela Ola, Ramón Fallon, Sinéad Cocchiglia, Vikrant Singh, Katherine M Sheehan, Fiona Bane and 8 more

Abstract read
In one paragraph

Article in Cancer communications (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Gavin P DowlingDepartment of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Gordon R DalyDepartment of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Aisling HegartyDepartment of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Michael FlanaganDepartment of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Mihaela OlaDepartment of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Ramón FallonDepartment of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Sinéad CocchigliaDepartment of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Vikrant SinghDepartment of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Katherine M SheehanDepartment of Pathology, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Fiona BaneDepartment of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Jason McGrathDepartment of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Louise WatsonDepartment of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Sandra HembrechtDepartment of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Bryan HennessyBeaumont RCSI Cancer Centre, Beaumont Hospital, Dublin, Ireland.
Patrick G MorrisBeaumont RCSI Cancer Centre, Beaumont Hospital, Dublin, Ireland.
Arnold D K HillDepartment of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Damir VarešlijaBeaumont RCSI Cancer Centre, Beaumont Hospital, Dublin, Ireland.
Leonie S YoungDepartment of Surgery, RCSI University of Medicine and Health Sciences, Dublin, Ireland.ORCID https://orcid.org/0000-0002-4904-0367

Funding

Breast Cancer Ireland 18239A01Breast Cancer Ireland program 18239A01Breast Cancer Now Fellowship Award with the generous 2019AugSF1310Science Foundation Ireland 18/SPP/3522Science Foundation Ireland 19/FFP/6443Science Foundation Ireland 20/FFP-P/8597Science Foundation Ireland Frontiers for the Future 19/FFP/6443Science Foundation Ireland Strategic Partnership Program, Precision Oncology Ireland 18/SPP/3522
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID39676516
PMCPMC11833670

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.