Evidence map›Paper›PMID 39676391›Full record

ArticleAdvanced healthcare materials2025

Streamlining the Highly Reproducible Fabrication of Fibrous Biomedical Specimens toward Standardization and High Throughput.

Zan Lamberger, Camilla Mussoni, Nicoletta Murenu, Mateo Andrade Mier, Philipp Stahlhut, Taufiq Ahmad, Natascha Schaefer, Carmen Villmann, Sarah Zwingelberg, Jürgen Groll and 1 more

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zan LambergerDepartment of Functional Materials in Medicine and Dentistry and Bavarian Polymer Institute, University of Würzburg, Pleicherwall 2, D-97070, Würzburg, Germany.ORCID 0000-0002-9814-5173
Camilla MussoniDepartment of Functional Materials in Medicine and Dentistry and Bavarian Polymer Institute, University of Würzburg, Pleicherwall 2, D-97070, Würzburg, Germany.ORCID 0009-0001-4878-4604
Nicoletta MurenuInstitute for Clinical Neurobiology, University Hospital Würzburg, Versbacherstr. 5, D-97078, Würzburg, Germany.
Mateo Andrade MierInstitute for Clinical Neurobiology, University Hospital Würzburg, Versbacherstr. 5, D-97078, Würzburg, Germany.
Philipp StahlhutDepartment of Functional Materials in Medicine and Dentistry and Bavarian Polymer Institute, University of Würzburg, Pleicherwall 2, D-97070, Würzburg, Germany.
Taufiq AhmadDepartment of Functional Materials in Medicine and Dentistry and Bavarian Polymer Institute, University of Würzburg, Pleicherwall 2, D-97070, Würzburg, Germany.ORCID 0000-0001-8435-4962
Natascha SchaeferInstitute for Clinical Neurobiology, University Hospital Würzburg, Versbacherstr. 5, D-97078, Würzburg, Germany.ORCID 0000-0001-9743-1963
Carmen VillmannInstitute for Clinical Neurobiology, University Hospital Würzburg, Versbacherstr. 5, D-97078, Würzburg, Germany.ORCID 0000-0003-1498-6950
Sarah ZwingelbergDepartment of Ophthalmology, University Hospital Düsseldorf, Merowingerplatz 1A, 40225, Düsseldorf, Germany.ORCID 0000-0001-9133-1099
Jürgen GrollDepartment of Functional Materials in Medicine and Dentistry and Bavarian Polymer Institute, University of Würzburg, Pleicherwall 2, D-97070, Würzburg, Germany.ORCID 0000-0003-3167-8466
Gregor LangDepartment of Functional Materials in Medicine and Dentistry and Bavarian Polymer Institute, University of Würzburg, Pleicherwall 2, D-97070, Würzburg, Germany.ORCID 0000-0001-9819-8630

Funding

Deutsche Forschungsgemeinschaft 326998133Deutsche Forschungsgemeinschaft 525934737
6 · The paper itself

Abstract

Soft nano- and microfiber-based polymer scaffolds bear enormous potential for their use in cell culture and tissue engineering since they mimic natural collagen structures and may thus serve as biomimetic adhesive substrates. They have, however, so far been restricted to small-scale production in research labs with high batch-to-batch variation. They are commonly produced via electrospinning or melt electrowriting and their delicate nature poses obstacles in detachment, storage, and transportation. This study focuses on overcoming challenges in the high throughput production and practical handling, introducing new methods to reproducibly prepare such scaffolds suitable for quantitative cell culture applications. Attention is given to the seamless handling and transfer of samples without compromising structural integrity. Challenges in detaching fibers without damage as well as storage, and transport are addressed. Cell culture studies demonstrate the methodological advantages, emphasizing the potential for standardized testing and biological readouts of these delicate fiber materials. The developed methods are applicable across various electrospinning and melt electrowriting approaches and can essentially contribute to their utilization in laboratory research and commercial applications.

Indexed as

Biocompatible MaterialsTissue EngineeringTissue ScaffoldsAnimalsHumansBiocompatible Materialselectrospinningfibersmelt‐electrowritingstandardizationupscale

Identifiers

PMID39676391
PMCPMC11804836

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.