Evidence map›Paper›PMID 39676114›Full record

SynthesisAnnals of surgical oncology2025

Effect of Minimally Invasive versus Open Distal Gastrectomy on Long-Term Survival in Patients with Gastric Cancer: Individual Patient Data Meta-analysis.

Matteo Calì, Davide Bona, Yoo Min Kim, Woojin Hyung, Francesco Cammarata, Gianluca Bonitta, Luigi Bonavina, Alberto Aiolfi

Abstract readMeta-AnalysisComparative StudyReview
PubMed Publisher
In one paragraph

Synthesis in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matteo CalìDivision of General Surgery, Department of Biomedical Science for Health, IRCCS Ospedale Galeazzi, Sant'Ambrogio Hospital, University of Milan, Milan, Italy.
Davide BonaDivision of General Surgery, Department of Biomedical Science for Health, IRCCS Ospedale Galeazzi, Sant'Ambrogio Hospital, University of Milan, Milan, Italy.
Yoo Min KimDivision of General Surgery, Department of Upper Gastrointestinal Surgery, Severance Hospital, Yonsei University, Seoul, South Korea.
Woojin HyungDivision of General Surgery, Department of Upper Gastrointestinal Surgery, Severance Hospital, Yonsei University, Seoul, South Korea.
Francesco CammarataDivision of General Surgery, Department of Biomedical Science for Health, IRCCS Ospedale Galeazzi, Sant'Ambrogio Hospital, University of Milan, Milan, Italy.
Gianluca BonittaDivision of General Surgery, Department of Biomedical Science for Health, IRCCS Ospedale Galeazzi, Sant'Ambrogio Hospital, University of Milan, Milan, Italy.
Luigi BonavinaDivision of General and Foregut Surgery, Department of Biomedical Sciences for Health, IRCCS Policlinico San Donato, University of Milan, Milan, Italy.
Alberto AiolfiDivision of General Surgery, Department of Biomedical Science for Health, IRCCS Ospedale Galeazzi, Sant'Ambrogio Hospital, University of Milan, Milan, Italy. alberto.aiolfi86@gmail.com.ORCID http://orcid.org/0000-0002-7764-6075

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMinimally invasive distal gastrectomy (MIDG) has been shown to improve short-term outcomes compared with open distal gastrectomy (ODG) in patients with early (EGC) and locally advanced gastric cancer (LAGC). The impact of MIDG on patient survival remains debated. This study aimed to compare the effect of MIDG versus ODG on long-term survival. PATIENTS AND

methodsRandomized clinical trial (RCTs) individual patient data (IPD) meta-analysis with restricted mean survival time difference (RMSTD) estimation. Scopus, MEDLINE, Web of Science, and ClinicalTrials.gov were searched. Primary outcomes were 5-year overall (OS), disease free survival (DFS), and cancer specific survival (CSS). RMSTD and 95% confidence intervals (CI) were used as pooled effect size measures. The certainty of evidence was categorized with the Grading of Recommendations, Assessment, Development, and Evaluation framework.

resultsOverall, ten RCTs (5297 patients) were included; 50.4% of patients underwent MIDG. At 60-months follow-up, the OS and DFS estimates for ODG versus MIDG were 0.41 months (95% CI - 0.17, 0.99; high level of certainty) and 0.42 months (95% CI - 0.38, 1.23; high level of certainty). CSS was specified in two RCTs, hence quantitative analysis was not practicable. The 60-month OS and DFS estimates for LAGC (five studies) were 0.32 months (95% CI - 0.80, 1.44; high level of certainty) and 0.31 months (95% CI - 2.02, 1.33; high level of certainty), respectively. The 36-month DFS appraisal for stage III patients (three studies) was - 0.41 months (95% CI - 26.1, 38.2; low level of certainty).

conclusionsThis meta-analysis found high-certainty evidence that MIDG and ODG demonstrate similar 5-year OS and DFS in patients with both EGC and LAGC.

Indexed as

GastrectomyMinimally Invasive Surgical ProceduresStomach NeoplasmsHumansPrognosisRandomized Controlled Trials as TopicSurvival RateDisease-free survivalLocally advanced gastric cancerMinimally invasive distal gastrectomyOpen distal gastrectomyOverall survival

Identifiers

PMID39676114

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.