ArticleProgress in orthodontics2024
The microbiome alterations of supragingival plaque among adolescents using clear aligners: a metagenomic sequencing analysis.
Article in Progress in orthodontics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Oral Microbiome and Metabolome Changes During Orthodontic Treatments: A Systematic Review of Limited Clinical Evidence.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Antibiofilm Activity of a Thermoformable Material Loaded With Essential Oil Solution.Clinical and experimental dental research · 2026Article
- Impacts of clean-up visualization techniques on excess composite of orthodontic attachments.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2026Article
- Anaerobic stress index to predict microbial ecological shifts in clear aligners.Journal of oral microbiology · 2026Article
- Metabolomic and metagenomic analyses reveal distinct microenvironmental signatures between clear aligner-associated and tooth surface dental plaque.BMC oral health · 2025Article
- Time-dependent microbiome dynamics in orthodontic thermoplastic materials: comparing PETG and TPU.Clinical oral investigations · 2025Article
- Biofilm Composition Changes During Orthodontic Clear Aligners Compared to Multibracket Appliances: A Systematic Review.Microorganisms · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundWhite spot lesions (WSLs) may develop in adolescents undergoing clear aligner (CA) therapy with poor oral hygiene. The specific effects of CAs on the microbial composition and functional characteristics of supragingival plaques remain unclear. The present study investigated the shift in the supragingival microbial community induced by CAs in adolescents through metagenomic technology.
methodsFifteen adolescents (12-15 years old) with Invisalign appliances were recruited. Supragingival plaque specimens were obtained twice, before treatment (T
resultsA total of 2,840,242,722 reads disclosed 180 phyla, 3,975 genera, and 16,497 microbiome species. During the first three months, the microbial community was relatively stable. The genus level revealed a higher relative abundance of Capnocytophaga, Neisseria, and Arachnia in the T
conclusionIn adolescents undergoing CA therapy with poor plaque control, caries progresses quickly within three months and noticeable WSLs develop on the tooth surface. Although the microbial community remained relatively steady and CA therapy did not cause significant changes in the overall functional gene composition in the first three months, virulence factors, including type IV pili and flagella, were more abundant and actively contributed to microorganism adhesion and biofilm formation.
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Registered trials
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