Evidence map›Paper›PMID 39676095›Full record

ArticleImmunologic research2024

Pinocembrin activation of DPP9 inhibits NLRP1 inflammasome activation to alleviate cerebral ischemia/reperfusion-induced lung and intestinal injury.

Po Wang, Liya Pan, Qianqian Liu, Yan Huang, Youlian Tang, Baoquan Lin, Yayun Liao, Hanwen Luo, Xiaoyan Meng

Abstract read
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In one paragraph

Article in Immunologic research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Po Wang *Department of Neurology, Liuzhou Workers Hospital, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, 545000, Guangxi Zhuang Autonomous Region, P.R. China.
Liya Pan *Department of Neurology, Liuzhou Workers Hospital, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, 545000, Guangxi Zhuang Autonomous Region, P.R. China.
Qianqian LiuDepartment of Neurology, Liuzhou Workers Hospital, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, 545000, Guangxi Zhuang Autonomous Region, P.R. China.
Yan HuangDepartment of Neurology, Liuzhou Workers Hospital, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, 545000, Guangxi Zhuang Autonomous Region, P.R. China.
Youlian TangDepartment of Neurology, Liuzhou Workers Hospital, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, 545000, Guangxi Zhuang Autonomous Region, P.R. China.
Baoquan LinDepartment of Neurology, Liuzhou Workers Hospital, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, 545000, Guangxi Zhuang Autonomous Region, P.R. China.
Yayun LiaoDepartment of Neurology, Liuzhou Workers Hospital, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, 545000, Guangxi Zhuang Autonomous Region, P.R. China.
Hanwen LuoDepartment of Scientific Research, Liuzhou Worker's Hospital, the Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, 545000, Guangxi Zhuang Autonomous Region, P.R. China.
Xiaoyan MengDepartment of Nephrology, Liuzhou Workers Hospital, the Fourth Affiliated Hospital of Guangxi Medical University, No. 156, Heping Road, Liunan District, Liuzhou, 545000, Guangxi Zhuang Autonomous Region, P.R. China. xiaoyan_M1182@163.com.

Funding

the Guangxi Natural Science Foundation project surface project NO.2023GXNSFAA026050the Key project of Guangxi Science and Technology Department No. AB22080096the Science and technology planning project of Liuzhou No. 2024YB0101A014
6 · The paper itself

Abstract

After stroke, there is a high incidence of acute lung injury and impairment of intestinal barrier function. In this research, the effects of pinocembrin on organ injuries induced by cerebral ischemia-reperfusion were investigated in mice with middle cerebral artery occlusion/reperfusion (MCAO/R) and further explored the possible mechanism. The potential targets of pinocembrin against MCAO/R were obtained by online tools. An MCAO/R model was developed in C57BL/6 J mice, in combination with pinocembrin administration and lentivirus-mediated gene intervention. Pinocembrin alleviated neurological impairment, reduced the volume of cerebral infarction, attenuated pathological injury of brain tissues in MCAO/R-induced mice by promoting the expression of dipeptidyl peptidase 9 (DPP9), and blocked the nucleotide-binding domain leucine-rich repeat pyrin domain containing 1 (NLRP1) inflammasome activation. Moreover, pinocembrin attenuated the infiltration of inflammatory cells in the lungs and intestinal histopathological injury induced by MCAO/R. The above effects of pinocembrin were reversed by knocking down DPP9. These findings indicated that pinocembrin inhibits NLRP1 inflammasome activation by inducing DPP9, thus mitigating brain, lung, and intestinal injuries induced by MCAO/R.

Indexed as

FlavanonesInflammasomesReperfusion InjuryAnimalsApoptosis Regulatory ProteinsBrain IschemiaDipeptidyl-Peptidases and Tripeptidyl-PeptidasesDisease Models, AnimalHumansInfarction, Middle Cerebral ArteryIntestinesLungMaleMiceMice, Inbred C57BLNLR ProteinsApoptosis Regulatory ProteinsDipeptidyl-Peptidases and Tripeptidyl-PeptidasesFlavanonesInflammasomesNLR ProteinspinocembrinDPP9Intestinal injuriesLung injuryMiddle cerebral artery occlusion/reperfusionNLRP1 inflammasomePinocembrin

Identifiers

PMID39676095

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.