Evidence map›Paper›PMID 39676094›Full record

ArticleLangenbeck's archives of surgery2024

The importance of microvascular invasion in patients with non-functioning pancreatic neuroendocrine neoplasm.

Wataru Izumo, Ryota Higuchi, Toru Furukawa, Masahiro Shiihara, Shuichiro Uemura, Takehisa Yazawa, Masakazu Yamamoto, Goro Honda

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In one paragraph

Article in Langenbeck's archives of surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wataru IzumoDepartment of Surgery, Institute of Gastroenterology, Tokyo Womens Medical University, 8-1 Kawada-cho, Tokyo, Shinjuku City, Japan.
Ryota HiguchiDepartment of Surgery, Institute of Gastroenterology, Tokyo Womens Medical University, 8-1 Kawada-cho, Tokyo, Shinjuku City, Japan. higuchi.ryota@twmu.ac.jp.
Toru FurukawaDepartment of Investigative Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Masahiro ShiiharaDepartment of Surgery, Institute of Gastroenterology, Tokyo Womens Medical University, 8-1 Kawada-cho, Tokyo, Shinjuku City, Japan.
Shuichiro UemuraDepartment of Surgery, Institute of Gastroenterology, Tokyo Womens Medical University, 8-1 Kawada-cho, Tokyo, Shinjuku City, Japan.
Takehisa YazawaGastrointestinal surgery, Utsunomiya Memorial Hospital, Utsunomiya, Japan.
Masakazu YamamotoGastrointestinal surgery, Utsunomiya Memorial Hospital, Utsunomiya, Japan.
Goro HondaDepartment of Surgery, Institute of Gastroenterology, Tokyo Womens Medical University, 8-1 Kawada-cho, Tokyo, Shinjuku City, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThe oncological importance of lymphatic, microvascular, and perineural invasions and their association with outcomes in patients with non-functioning pancreatic neuroendocrine neoplasm (NF-PanNEN) remains unclear. We aimed to investigate the role of these factors in the prognosis of patients with NF-PanNEN.

methodsWe retrospectively analyzed 115 patients who underwent curative resection and were pathologically and clinically diagnosed with NF-PanNEN. We evaluated the relationship between clinicopathological factors and recurrence.

resultsThirty (26%), 38 (33%), and 11 (10%) patients had lymphatic, microvascular, and nerve invasions, respectively. Twenty-one patients (18%) experienced recurrence, with a median time to recurrence of 2.6 years (range: 0.3-8.2). The 3-, 5-, and 10-year recurrence-free survival (RFS) rates were 88.3%, 84.4%, and 79.1%, respectively. In multivariate analyses, World Health Organization Grade G2-3 (vs. G1, hazard ratio (HR): 16.2), T factor T3-4 (vs. T1-2, HR: 5.2), and the presence of microvascular invasion (vs. absence, HR: 5.6) were significant risk factors for RFS. When these risk factors were assigned as risk score of three, one, and one points depending on the HR, the 5-year recurrence rates in patients with risk score groups 0-1 and 2-5 were 98.6% and 53.3%, (P < 0.001). Moreover, only the presence of microvascular invasion significantly increased the likelihood of recurrence within 3 years.

conclusionsThe presence of microvascular invasion is an independent risk factor for recurrence in patients with NF-PanNEN. Our risk scoring system, which includes "the presence of microvascular invasion," may be useful for predicting recurrence.

Indexed as

Neoplasm InvasivenessNeoplasm Recurrence, LocalPancreatic NeoplasmsAdultAgedAged, 80 and overFemaleHumansMaleMicrovesselsMiddle AgedNeuroendocrine TumorsPancreatectomyPrognosisRetrospective StudiesLymphatic invasionMicrovascular invasionNerve invasionNon-functioning pancreatic neuroendocrine neoplasmRecurrence

Identifiers

PMID39676094

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.