Evidence map›Paper›PMID 39675569›Full record

ReviewJournal of thrombosis and haemostasis : JTH2025

Transfusion biomaterials for hemostasis.

Ethan Pozy, Ashley C Brown

Abstract readReview
In one paragraph

Review in Journal of thrombosis and haemostasis : JTH, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Platelet Products and Artificial Platelets for Regenerative Medicine.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ethan PozyJoint Department of Biomedical Engineering of University of North Carolina, Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA; Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27606, USA.
Ashley C BrownJoint Department of Biomedical Engineering of University of North Carolina, Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA; Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27606, USA. Electronic address: aecarso2@ncsu.edu.

Funding

Anti-microbial platelet-like-particles to treat internal bleeding and augment subsequent healingR01HL162809 · NHLBI · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Ashley Carson Brown · 2023 to 2026
$2.3M
NC State Chemistry of Life Training Program (CLTP)T32GM141887 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI PIERCE, JOSHUA G. · 2021 to 2025
$1.3M
NHLBI NIH HHS R01 HL162809NIGMS NIH HHS T32 GM141887
6 · The paper itself

Abstract

Bleeding is a leading cause of trauma deaths and surgical complications. Excessive bleeding has traditionally been treated with the transfusion of donated blood. However, the complicated logistics of sourcing and storing donated blood increases the cost and reduces the accessibility of treatment, particularly as rates of blood donation decline. Advances in biomaterials for targeted drug delivery have presented the opportunity for alternative synthetic injectable hemostats. Among these leading technologies are lipid and polymeric particles and polymer platforms that bind to ligands present at wound sites and amplify hemostatic pathways. As leading hemostatic biomaterials advance toward clinical application, we review current preclinical research models and findings as well as future research directions for next-generation biomaterial injectable hemostatic technologies.

Indexed as

Biocompatible MaterialsBlood TransfusionHemorrhageHemostasisHemostaticsAnimalsDrug Delivery SystemsHumansBiocompatible MaterialsHemostaticsbiocompatible materialsblood plateletshemostasisnanoparticle drug delivery systemtransfusion medicine

Identifiers

PMID39675569
PMCPMC12989981

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.