Evidence map›Paper›PMID 39674987›Full record

ArticlePediatric surgery international2024

Factors affecting inflammatory changes in congenital lung malformations.

Andrea Zulli, Francesca Tocchioni, Chiara Oreglio, Chiara Caporalini, Anna Maria Buccoliero, Antonino Morabito, Francesco Morini

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Article in Pediatric surgery international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Andrea ZulliDepartment of Pediatric Thoracic Neonatal and Urological Surgery, Meyer Children's Hospital IRCCS, Viale G.Pieraccini 24, 50139, Florence, Italy. andrea.zulli@meyer.it.ORCID http://orcid.org/0000-0001-6420-7025
Francesca TocchioniDepartment of Pediatric Thoracic Neonatal and Urological Surgery, Meyer Children's Hospital IRCCS, Viale G.Pieraccini 24, 50139, Florence, Italy.
Chiara OreglioDepartment of Pediatric Thoracic Neonatal and Urological Surgery, Meyer Children's Hospital IRCCS, Viale G.Pieraccini 24, 50139, Florence, Italy.
Chiara CaporaliniPathology Unit, Meyer Children's Hospital IRCCS, University of Florence, Florence, Italy.
Anna Maria BuccolieroPathology Unit, Meyer Children's Hospital IRCCS, University of Florence, Florence, Italy.
Antonino MorabitoDepartment of Pediatric Thoracic Neonatal and Urological Surgery, Meyer Children's Hospital IRCCS, Viale G.Pieraccini 24, 50139, Florence, Italy.
Francesco MoriniNeurofarba Department, University of Florence, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aim of the studyPatients with congenital lung malformation (CLM) may present pulmonary inflammatory changes. However, little is known about the factors influencing local inflammation. The aim of this study was to evaluate the factors that may affect inflammatory changes in CLM.

methodsPatients with CLM operated upon between 2005 and 2021 were included. The grade of inflammation was defined with a purpose-made inflammatory score (IS) ranging from 0 to 5. The association of type of CLM and age at surgery with IS was analyzed. Results are means (standard deviation). MAIN

resultsData from 105 patients with CLM were collected, 56 had congenital pulmonary airways malformation (CPAM), 24 bronchopulmonary sequestration (BPS), and 25 congenital lobar emphysema (CLE). 91 patients (87%) had inflammatory changes. IS was 2.1 (1.5), 1.2 (1.0), and 1.3 (1.5) in CPAM, BPS, and CLE respectively (One-way ANOVA p = 0.0101). CPAM showed a significantly higher IS as compared with BPS (p = 0.0242) and CLE (p = 0.0495). Age at operation significantly correlated to IS (r

conclusionsPatients with CLMs often present inflammatory changes in their lungs. Grade of inflammation significantly correlates with age at surgery and type of anomaly, with CPAMs having the highest grade. These findings support early resection in patients with CLM, especially in case of CPAM.

Indexed as

LungBronchopulmonary SequestrationChildChild, PreschoolFemaleHumansInfantInfant, NewbornInflammationMalePulmonary EmphysemaRetrospective StudiesCongenital lung malformationInflammation scorePediatric surgeryPulmonary resection

Identifiers

PMID39674987

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