ArticleDocumenta ophthalmologica. Advances in ophthalmology2025
Brief report: effects of methylphenidate on the light adapted electroretinogram.
Article in Documenta ophthalmologica. Advances in ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- ERG-Graph: Graph Signal Processing of the Electroretinogram for Classification of Neurodevelopmental Disorders.Bioengineering (Basel, Switzerland) · 2026Article
- Synthetic electroretinogram signal generation using a conditional generative adversarial network.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Remodeling the light-adapted electroretinogram using a bayesian statistical approach.BMC research notes · 2025Article
- Spectral Analysis of Light-Adapted Electroretinograms in Neurodevelopmental Disorders: Classification with Machine Learning.Bioengineering (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo explore changes in the electroretinogram (ERG) following methylphenidate use in attention-deficit/hyperactivity disorder (ADHD).
methodsLight adapted ERGs were recorded in five individuals (3 male and 2 female, age range 13.6-21.8 years) with a diagnosis of ADHD. Six flash strengths ranging from 71 to 446 Td.s were qualitatively evaluated following a minimum of 24 h without any medication and from 2 to 6 h following the individuals' standard slow-release (XL) methylphenidate dose that ranged from 18 to 60 mg.
resultsOf the six flash strengths, the 178 Td.s strength revealed changes in four of the five participants with a median 27.4% increase in b-wave amplitude. For three individuals there was an increase in the a-wave amplitude and for two of the same individuals there was also a noticeable pronouncement of the oscillatory potentials. The a-wave amplitude showed a greatest median increase at the 446 Td.s flash strength of 25.8%. One individual - on the highest dose (60 mg) exhibited no morphologically distinct changes in the ERG. No differences in the time to peaks of the a- and b-wave were observed for any individual.
conclusionThe a- and b-wave amplitudes of the light adapted ERG could provide insights into the effect of methylphenidate in ADHD.
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