ArticleJournal of clinical laboratory analysis2025
Digital Imaging of Peripheral Blood Smear With MC-80 as a Screening Tool for Thalassemia.
Article in Journal of clinical laboratory analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Prediction ofFrontiers in medicine · 2026Article
- Clinical application study of a novel fully automatic erythrocyte osmotic fragility analysis system.Biochemistry and biophysics reports · 2025Article
- Automated Morphologic Differentiation Between Iron Deficiency Anemia and Thalassemia.Journal of clinical laboratory analysis · 2025Article
- Real-World Application of Digital Morphology Analyzers: Practical Issues and Challenges in Clinical Laboratories.Diagnostics (Basel, Switzerland) · 2025Review
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3 authors.
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Abstract
backgroundThalassemia, a genetic blood disorder, poses significant global health challenges, emphasizing the importance of accurate screening methods. Traditional diagnostic tools, such as osmotic fragility and dichlorophenolindophenol tests, along with blood indices, such as mean corpuscular volume and mean corpuscular hemoglobin, have limitations. Digital microscopy of peripheral blood smears is a promising alternative for objective quantification and standardization.
methodsBlood samples from 81 thalassemia screening-negative and 41 screening-positive individuals were analyzed using Mindray MC-80 Digital Morphology.
resultsPre-classification of red blood cell (RBC) morphology using Mindray MC-80 revealed significant differences between the screening-positive and screening-negative groups. Various RBC morphologies demonstrated statistically significant variance, including hypochromic cells, schistocytes, elliptocytes, target cells, teardrop cells (p < 0.001), and ovalocytes (p = 0.002). However, the area under the receiver operating characteristic curve of these parameters was < 0.8, indicating a limited discriminatory power.
conclusionRBC morphology showed promise in detecting subtle changes associated with thalassemia. However, it may not be sufficient for accurate screening alone, highlighting the need for complementary diagnostic approaches.
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