Evidence map›Paper›PMID 39674913›Full record

ArticleMicrobiology and immunology2025

Lonidamine, a Novel Modulator for the BvgAS System of Bordetella Species.

Natsuko Ota, Takashi Nishida, Daron M Standley, Aalaa Alrahman Sherif, Satoshi Iwano, Dendi Krisna Nugraha, Toshiya Ueno, Yasuhiko Horiguchi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology and immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Natsuko OtaDepartment of Molecular Bacteriology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.ORCID http://orcid.org/0009-0005-4816-0681
Takashi NishidaDepartment of Molecular Bacteriology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.ORCID http://orcid.org/0000-0003-4978-7716
Daron M StandleyDepartment of Genome Informatics, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.ORCID http://orcid.org/0000-0003-4078-0817
Aalaa Alrahman SherifDepartment of Genome Informatics, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Satoshi IwanoInstitute for Tenure Track Promotion, University of Miyazaki, Miyazaki, Japan.ORCID http://orcid.org/0000-0003-3757-1504
Dendi Krisna NugrahaDepartment of Molecular Bacteriology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.ORCID http://orcid.org/0000-0002-6995-5695
Toshiya UenoDepartment of Molecular Bacteriology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Yasuhiko HoriguchiDepartment of Molecular Bacteriology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.ORCID http://orcid.org/0000-0002-1592-5861

Funding

This research was supported by JSPS KAKENHI (Grant Numbers; 23K27408, 23H02717, and 21K19378), JST SPRING (Grant Number JPMJSP2138), The Nippon Foundation-Osaka University Project for Infectious Disease Prevention, and Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research [BINDS]) from AMED under Grant Number JP21am0101001 (support number 3241).
6 · The paper itself

Abstract

The Gram-negative bacteria Bordetella pertussis, B. parapertussis, and B. bronchiseptica cause respiratory diseases in various mammals. They share the BvgAS two-component system, which regulates the phenotypic conversion between the virulent Bvg

Indexed as

Bacterial ProteinsBordetellaTranscription FactorsAnimalsBordetella bronchisepticaBordetella InfectionsBordetella parapertussisBordetella pertussisGene Expression Regulation, BacterialMiceSignal TransductionVirulenceVirulence FactorsBacterial ProteinsBvgA protein, BacteriabvgS protein, Bordetella pertussisTranscription FactorsVirulence FactorsBordetellaBvgASlonidaminemodulatorphase conversion

Identifiers

PMID39674913
PMCPMC11873758

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.